Benavides-Rodríguez Lorena, García-Hermoso Antonio, Rodrigues-Bezerra Diogo, Izquierdo Mikel, Correa-Bautista Jorge Enrique, Ramírez-Vélez Robinson
Centro de Estudios para la Medición de la Actividad Física (CEMA), Escuela de Medicina y Ciencias de la Salud, Universidad del Rosario, Bogotá DC 111221, Colombia.
Laboratorio de Ciencias de la Actividad Física, el Deporte y la Salud, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, USACH, Región Metropolitana, Santiago 7500618, Chile.
Nutrients. 2017 Jul 4;9(7):695. doi: 10.3390/nu9070695.
This study explored the mediating factors of sarcopenia in a group of women survivors of breast cancer in Bogotá, Colombia. This was a descriptive cross-sectional study with 98 women survivors of breast cancer, who were registered with the SIMMON (Integrated Synergies to Improve Oncological Management in Colombia) Foundation. Body weight, height, and waist circumference (WC) were measured, and body mass index (BMI) was calculated. Body composition (percentage of fat and muscle mass) was evaluated via four-pole bioelectrical impedance analysis. Sarcopenia was defined as low muscle mass plus low grip strength or low gait speed (European Working Group on Sarcopenia in Older People (EWGSOP) criteria). A "causal" mediation analysis with the Baron & Kenny procedure (PROCESS macro, Columbus, OH, USA) was used to explore variables related to sarcopenia. Analyses were performed with the IBM SPSS 21 statistical package (SPSS Inc., Chicago, IL, USA). The significance level of the results obtained in the hypothesis contrast was < 0.05. The mean age of the sample was 65.5 ± 5.9 years, with a BMI of 27.8 ± 4.7 kg/m². The prevalence of sarcopenia was 22.4%. Linear regression models suggest a partial mediation of anthropometric parameters (body mass, body mass index and waist circumference) in the association between handgrip strength and muscle mass. In conclusion, one in every five women survivors of breast cancer had sarcopenia. The findings seem to emphasize the importance of obesity prevention in women survivors of breast cancer, suggesting that high handgrip strength may not relate closely to greater muscle mass and therefore would not exclude the risk of sarcopenia.
本研究探讨了哥伦比亚波哥大一组乳腺癌女性幸存者中肌肉减少症的中介因素。这是一项描述性横断面研究，研究对象为98名乳腺癌女性幸存者，她们均在SIMMON（哥伦比亚改善肿瘤管理综合协同效应）基金会登记注册。测量了体重、身高和腰围（WC），并计算了体重指数（BMI）。通过四极生物电阻抗分析评估身体成分（脂肪和肌肉质量百分比）。肌肉减少症的定义为低肌肉量加上低握力或低步速（欧洲老年人肌肉减少症工作组（EWGSOP）标准）。采用Baron & Kenny程序（PROCESS宏程序，美国俄亥俄州哥伦布市）进行“因果”中介分析，以探究与肌肉减少症相关的变量。使用IBM SPSS 21统计软件包（美国伊利诺伊州芝加哥市SPSS公司）进行分析。假设对比中获得的结果的显著性水平<0.05。样本的平均年龄为65.5±5.9岁，BMI为27.8±4.7kg/m²。肌肉减少症的患病率为22.4%。线性回归模型表明，人体测量参数（体重、体重指数和腰围）在握力与肌肉量之间的关联中起部分中介作用。总之，每五名乳腺癌女性幸存者中就有一人患有肌肉减少症。研究结果似乎强调了乳腺癌女性幸存者预防肥胖的重要性，表明高握力可能与更大的肌肉量没有密切关系，因此不能排除肌肉减少症的风险。
