Department of Physiotherapy, University of Malaga, C/ Arquitecto Peñalosa, 3, 29071, Málaga, Spain.
Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.
Sci Rep. 2022 Sep 7;12(1):15148. doi: 10.1038/s41598-022-19532-7.
Ultrasound imaging texture analyses may provide information on tissue homogeneity changes in metastatic breast cancer (MBC) through second-order analyzes based on the gray-level co-occurrence matrix. This study aimed to analyze the responsiveness and correlations of biomarkers of muscular and fat echotexture after an exercise intervention in women with MBC. A 12-week exercise intervention was conducted in 2019, including aerobic and strength training. Echotexture variables were obtained at baseline and after intervention from the quadriceps (Q) and biceps brachii and brachialis. Mean differences were calculated using the T-Student parametric test for dependent samples of the differences in the means (P = 0.05; 95% CI). Data obtained from 13 MBC women showed significant differences in some echotexture variables after the intervention. QLQ-BR23 questionnaire correlated with several echotexture variables from muscle and subcutaneous fat. PFS-R scale correlated positively with the Q Subcutaneous Fat Non-Contraction Homogeneity (R = 0.43, P < 0.05). Q Muscle Non-Contraction Energy and Q Muscle Non-Contraction Textural Correlation explained 90% of the variance of QLQ-BR23. Some muscle and subcutaneous fat echotexture biomarkers showed good responsiveness after the exercise intervention. Additionally, some muscle and subcutaneous fat variables correlated with QLQ-BR23 and cancer-related fatigue measured by PFS-R scale in MBC patients.Trial registration: NCT03879096.
超声成像纹理分析可以通过基于灰度共生矩阵的二阶分析，为转移性乳腺癌（MBC）的组织均质性变化提供信息。本研究旨在分析 MBC 女性在运动干预后肌肉和脂肪回声纹理生物标志物的反应性和相关性。2019 年进行了为期 12 周的运动干预，包括有氧运动和力量训练。在基线和干预后从股四头肌（Q）和肱二头肌和肱肌获得回声纹理变量。使用 T 检验学生参数检验对均值差异进行计算（P = 0.05；95%置信区间）。从 13 名 MBC 女性获得的数据显示，干预后一些回声纹理变量存在显著差异。QLQ-BR23 问卷与肌肉和皮下脂肪的一些回声纹理变量相关。PFS-R 量表与 Q 皮下脂肪非收缩均匀性呈正相关（R = 0.43，P < 0.05）。Q 肌肉非收缩能量和 Q 肌肉非收缩纹理相关性解释了 QLQ-BR23 的 90%方差。一些肌肉和皮下脂肪回声纹理生物标志物在运动干预后表现出良好的反应性。此外，一些肌肉和皮下脂肪变量与 MBC 患者的 QLQ-BR23 和 PFS-R 量表测量的癌症相关疲劳相关。试验注册：NCT03879096。
