Khader Basel A, Peel Sean A F, Towler Mark R
Department of Mechanical Engineering, Faculty of Engineering and Architectural Science, Ryerson University, 350 Victoria Street, Toronto, ON M5B 2K3, Canada.
Keenan Research Centre, St. Michael's Hospital, Toronto, ON M5B 1T8, Canada.
J Funct Biomater. 2017 Jul 5;8(3):25. doi: 10.3390/jfb8030025.
Glass polyalkenoate cements (GPCs) have potential as bio-adhesives due to their ease of application, appropriate mechanical properties, radiopacity and chemical adhesion to bone. Aluminium (Al)-free GPCs have been discussed in the literature, but have proven difficult to balance injectability with mechanical integrity. For example, zinc-based, Al-free GPCs reported compressive strengths of 63 MPa, but set in under 2 min. Here, the authors design injectable GPCs (IGPCs) based on zinc-containing, Al-free silicate compositions containing GeO₂, substituted for ZnO at 3% increments through the series. The setting reactions, injectability and mechanical properties of these GPCs were evaluated using both a hand-mix (h) technique, using a spatula for sample preparation and application and an injection (i) technique, using a 16-gauge needle, post mixing, for application. GPCs ability to act as a carrier for bovine serum albumin (BSA) was also evaluated. Germanium (Ge) and BSA containing IGPCs were produced and reported to have working times between 26 and 44 min and setting times between 37 and 55 min; the extended handling properties being as a result of less Ge. The incorporation of BSA into the cement had no effect on the handling and mechanical properties, but the latter were found to have increased compression strength with the addition of Ge from between 27 and 37 MPa after 30 days maturation.
玻璃聚链烯酸酯粘固粉（GPCs）因其易于应用、合适的机械性能、射线不透性以及与骨的化学粘附性而具有作为生物粘合剂的潜力。文献中已讨论过无铝GPCs，但已证明难以在可注射性与机械完整性之间取得平衡。例如，据报道，无铝的锌基GPCs抗压强度为63 MPa，但在2分钟内就凝固了。在此，作者基于含锌的无铝硅酸盐组合物设计了可注射GPCs（IGPCs），该组合物含有GeO₂，在整个系列中以3%的增量替代ZnO。使用手工混合（h）技术（使用刮刀进行样品制备和应用）和注射（i）技术（使用16号针头，混合后进行应用）对这些GPCs的凝固反应、可注射性和机械性能进行了评估。还评估了GPCs作为牛血清白蛋白（BSA）载体的能力。制备了含锗（Ge）和BSA的IGPCs，据报道其工作时间在26至44分钟之间，凝固时间在37至55分钟之间；延长的操作性能是由于Ge含量较低。将BSA掺入粘固粉对操作和机械性能没有影响，但发现后者在成熟30天后随着Ge的添加抗压强度从27至37 MPa增加。
