Youn Sung Hye, Kwon Joo Hee, Yin Jun, Tam Le Thi, Ahn Hye Shin, Myung Soon Chul, Lee Min Won
Laboratory of Pharmacognosy and Natural Product Derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
Department of Urology, College of Medicine, Chung-Ang University, Seoul 156-756, Korea.
Molecules. 2017 Jul 5;22(7):1121. doi: 10.3390/molecules22071121.
Bume (QGB, family Fagaceae) is a tall evergreen oak species tree that grows in warm temperate regions in Korea, Japan, China and Taiwan. plants have long been the basis of traditional medicines. Their clinical benefits according to traditional medicine include relief of urolithiasis, tremors and inflammation. In the present study, the anti-urolithiasis activity including anti-inflammatory and anti-oxidative activities, of some phenolic compounds isolated from QGB were described. Seven compounds were isolated and identified as picraquassioside D (), quercussioside (), (+)-lyoniresinol-9'α--β-d-xylopyranoside (), (+)-catechin (), (-)-epicatechin (), procyanidin B-3 (), and procyanidin B-4 (). Compounds - showed potent anti-oxidative and anti-inflammatory activities. These compounds were further tested for their inhibition of the gene expression of the inflammatory cytokines. The three compounds - showed dose-dependent inhibitory activities on gene expression of COX-2 and IL-1β. In vivo, urolithiasis was induced more effectively in an animal model of acute urolithiasis by the administration of QGB extract. These results indicate the potential of compounds from QGB in the treatment of urolithiasis.
槲栎（壳斗科，青冈属）是一种高大的常绿栎类树种，生长于韩国、日本、中国和台湾的暖温带地区。该植物长期以来一直是传统药物的基础。根据传统医学，其临床益处包括缓解尿路结石、震颤和炎症。在本研究中，描述了从槲栎中分离出的一些酚类化合物的抗尿路结石活性，包括抗炎和抗氧化活性。分离并鉴定出七种化合物，分别为苦木素D、栎苷、（+）-去甲二氢愈创木脂素-9'α-β-D-吡喃木糖苷、（+）-儿茶素、（-）-表儿茶素、原花青素B-3和原花青素B-4。化合物 - 显示出强大的抗氧化和抗炎活性。进一步测试了这些化合物对炎性细胞因子基因表达的抑制作用。化合物 - 对COX-2和IL-1β的基因表达表现出剂量依赖性抑制活性。在体内，通过给予槲栎提取物，在急性尿路结石动物模型中更有效地诱导了尿路结石。这些结果表明槲栎中的化合物在治疗尿路结石方面具有潜力。
