School of Functional Food and Wine, Shenyang Pharmaceutical University, Shenyang 110016, China.
Key Laboratory of Structure-Based Drug Design and Discovery of Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China.
Molecules. 2018 Aug 28;23(9):2167. doi: 10.3390/molecules23092167.
Acorn leaves, which possess potential pharmacologic effects, are traditionally consumed as food in China. Phytochemical investigations of acorn leaves yielded one new and 25 known polyphenols, and their structures were identified by extensive spectroscopic analysis. Three antidiabetes assays were conducted. Compound considerably increased the survival of pancreatic beta cells by reducing the production of reactive oxygen species and enhancing the activities of superoxide dismutase, catalase, and glutathione in MIN6 cells damaged by H₂O₂. The preliminary mechanism by which compound protects pancreatic beta cells was through the nuclear factor erythroid-2-related factor 2 (Nrf2)/heme oxygenase-1 HO-1 pathway. Most of the tested isolates showed strong inhibitory activity against α-glucosidase and protein tyrosine phosphatase 1B. The IC values of most compounds were much lower than those of the positive control. The results suggest that polyphenols from acorn leaves are potential functional food ingredients that can be used as antidiabetic agents.
橡树叶具有潜在的药理作用，在中国传统上被用作食物。对橡树叶的植物化学研究得到了一个新的和 25 个已知的多酚，它们的结构通过广泛的光谱分析来确定。进行了三种抗糖尿病测定。化合物通过减少活性氧的产生和增强超氧化物歧化酶、过氧化氢酶和谷胱甘肽在过氧化氢损伤的 MIN6 细胞中的活性，显著增加了胰腺β细胞的存活。化合物保护胰腺β细胞的初步机制是通过核因子红细胞 2 相关因子 2（Nrf2）/血红素加氧酶 1（HO-1）途径。大多数测试分离物对α-葡萄糖苷酶和蛋白酪氨酸磷酸酶 1B 表现出强烈的抑制活性。大多数化合物的 IC 值远低于阳性对照。结果表明，来自橡树叶的多酚是潜在的功能性食品成分，可以用作抗糖尿病药物。
