Kim Shin-Hye, Shin Hye-Lim, Son Tae Hyun, Lim So-An, Kim Dongsoo, Yoon Jun-Hyuck, Choi Hyunmo, Kim Hwan-Gyu, Choi Sik-Won
Forest Biomaterials Research Center, National Institute of Forest Science (NIFoS), Jinju 52817, Republic of Korea.
Department of Biological Sciences, Jeonbuk National University, Jeonju 54896, Republic of Korea.
Biology (Basel). 2024 Sep 28;13(10):775. doi: 10.3390/biology13100775.
The skin, recognized as the largest organ in the human body, serves a vital function in safeguarding against external threats. Severe damage to the skin can pose significant risks to human health. There is an urgent requirement for safe and effective therapies for wound healing. While phytotherapy has been widely utilized for various health conditions, the potential of in promoting wound healing has not been thoroughly explored. is a cultivated crop known for its abundance of bioactive compounds. This study examined the wound-healing properties of acorn seed coat water extract (QGASE). The findings from the study suggest that QGASE promotes wound closure in HF cells by upregulating essential markers related to the wound-healing process. Additionally, QGASE demonstrates antioxidant effects, mitigating oxidative stress and aiding in recovery from injuries induced by HO. In vivo experiments provide additional substantiation supporting the efficacy of QGASE in enhancing wound healing. The collective results indicate that QGASE may be a promising candidate for the development of innovative therapeutic strategies aimed at enhancing skin wound repair.
皮肤被认为是人体最大的器官，在抵御外部威胁方面发挥着至关重要的作用。皮肤的严重损伤会对人类健康构成重大风险。迫切需要安全有效的伤口愈合疗法。虽然植物疗法已被广泛用于各种健康状况，但[具体植物名称]在促进伤口愈合方面的潜力尚未得到充分探索。[具体植物名称]是一种种植作物，以其丰富的生物活性化合物而闻名。本研究考察了[具体植物名称]橡子种皮水提取物（QGASE）的伤口愈合特性。该研究结果表明，QGASE通过上调与伤口愈合过程相关的关键标志物来促进HF细胞的伤口闭合。此外，QGASE具有抗氧化作用，可减轻氧化应激并有助于从HO诱导的损伤中恢复。体内实验进一步证实了QGASE在促进伤口愈合方面的功效。总体结果表明，QGASE可能是开发旨在增强皮肤伤口修复的创新治疗策略的有前途的候选物。
