AstraZeneca R&D Gothenburg, Pepparedsleden 1, Mölndal, SE-431 83, Sweden.
Nanoscale. 2017 Aug 17;9(32):11410-11417. doi: 10.1039/c7nr03261g.
Atomic layer deposition on pharmaceutical particles for drug delivery applications is demonstrated using assisted fluidized bed dry powder processing. Complete and conformal layering is achieved on particle sizes from the lower micron to upper nanometer range under near ambient conditions. As few as 2-14 atomic alumina layers alter particle properties: dissolution, dispersibility and heat transfer.
在药物输送应用中，通过辅助流化床干粉处理技术对药物颗粒进行原子层沉积。在接近环境条件下，可在从微米到纳米的颗粒尺寸范围内实现完全和一致的层状沉积。只需 2-14 个原子氧化铝层就可以改变颗粒的性质：溶解、分散性和传热。
