Dutra Bernardo Carvalho, Oliveira Alcione Maria Soares Dutra, Oliveira Peterson Antônio Dutra, Manzi Flavio Ricardo, Cortelli Sheila Cavalca, Cota Luís Otávio de Miranda, Costa Fernando Oliveira
Universidade Federal de Minas Gerais, Faculdade de Odontologia, Departamento de Patologia e Cirurgia. Belo Horizonte, MG, Brasil.
Pontífica Universidade Católica of Minas Gerais, Departamento de Periodontia. Belo Horizonte, MG, Brasil.
J Appl Oral Sci. 2017 May-Jun;25(3):310-317. doi: 10.1590/1678-7757-2016-0252.
Few studies have evaluated the effect of the topical application of sodium alendronate (ALN) on the treatment of intrabuccal bone defects, especially those caused by periodontitis. This 6-month randomized placebo controlled clinical trial aimed at evaluating the effect of non-surgical periodontal treatment associated with the use of 1% ALN, through clinical evaluations and cone-beam computed tomography (CBCT).
Twenty individuals with chronic periodontitis underwent periodontal examination at the baseline as well as 3 and 6 months after periodontal treatment, registering clinical attachment level (CAL), periodontal probing depth (PPD), and bleeding on probing (BOP) as the clinical outcomes. After manual scaling and root planing, 40 bilateral sites with interproximal vertical bone defects were randomly treated with either 1% ALN gel or a placebo. Bone defects were evaluated through CBCT at the baseline and 6 months post-treatment. The clinical and CBCT parameters were compared using the Wilcoxon and Friedman tests (p<0.05).
Although ALN produced a greater CAL gain when compared to the placebo at 6 months post-treatment (p=0.021), both treatments produced similar effects on the PPD, BOP, and bone height. Significant differences in bone fill were observed only in patients of the ALN group (4.5 to 3.8 mm; p=0.003) at 6 months post-treatment.
Topical application of 1% ALN might be a beneficial adjuvant to non-surgical periodontal therapy.
很少有研究评估局部应用阿仑膦酸钠（ALN）治疗口腔内骨缺损的效果，尤其是由牙周炎引起的骨缺损。这项为期6个月的随机安慰剂对照临床试验旨在通过临床评估和锥形束计算机断层扫描（CBCT），评估与使用1%ALN相关的非手术牙周治疗的效果。
20名慢性牙周炎患者在基线以及牙周治疗后3个月和6个月接受牙周检查，记录临床附着水平（CAL）、牙周探诊深度（PPD）和探诊出血（BOP）作为临床结果。在进行手工洁治和根面平整后，40个双侧存在邻面垂直骨缺损的部位被随机用1%ALN凝胶或安慰剂进行治疗。在基线和治疗后6个月通过CBCT评估骨缺损情况。使用Wilcoxon和Friedman检验比较临床和CBCT参数（p<0.05）。
尽管在治疗后6个月时，与安慰剂相比，ALN使CAL有更大程度的增加（p=0.021），但两种治疗方法对PPD、BOP和骨高度产生的效果相似。仅在ALN组患者中，治疗后6个月时观察到骨填充有显著差异（从4.5毫米至3.8毫米；p=0.003）。
局部应用1%ALN可能是非手术牙周治疗的有益辅助手段。
