Sharma Anuj, Raman Achala, Pradeep Avani Raju
Dental Pearl, Jharkhand, India.
Government Dental College and Research Institute, Department of Periodontics, Bangalore, Karnataka, India.
J Appl Oral Sci. 2017 May-Jun;25(3):243-249. doi: 10.1590/1678-7757-2016-0201.
Alendronate (ALN) inhibits osteoclastic bone resorption and triggers osteostimulative properties both in vivo and in vitro, as shown by increase in matrix formation. This study aimed to explore the efficacy of 1% ALN gel as local drug delivery (LDD) in adjunct to scaling and root planing (SRP) for the treatment of chronic periodontitis among smokers.
75 intrabony defects were treated in 46 male smokers either with 1% ALN gel or placebo gel. ALN gel was prepared by adding ALN into carbopol-distilled water mixture. Clinical parameters [modified sulcus bleeding index, plaque index, probing depth (PD), and periodontal attachment level (PAL)] were recorded at baseline, at 2 months, and at 6 months, while radiographic parameters were recorded at baseline and at 6 months. Defect fill at baseline and at 6 months was calculated on standardized radiographs by using the image analysis software.
Mean PD reduction and mean PAL gain were found to be greater in the ALN group than in the placebo group, both at 2 and 6 months. Furthermore, a significantly greater mean percentage of bone fill was found in the ALN group (41.05±11.40%) compared to the placebo group (2.5±0.93%).
The results of this study showed 1% ALN stimulated a significant increase in PD reduction, PAL gain, and an improved bone fill compared to placebo gel in chronic periodontitis among smokers. Thus, 1% ALN, along with SRP, is effective in the treatment of chronic periodontitis in smokers.
阿仑膦酸盐（ALN）可抑制破骨细胞的骨吸收，并在体内和体外引发骨刺激特性，如基质形成增加所示。本研究旨在探讨1%阿仑膦酸盐凝胶作为局部给药（LDD）辅助龈下刮治术和根面平整术（SRP）治疗吸烟者慢性牙周炎的疗效。
46名男性吸烟者的75个骨内缺损，分别用1%阿仑膦酸盐凝胶或安慰剂凝胶治疗。阿仑膦酸盐凝胶是通过将阿仑膦酸盐加入卡波姆-蒸馏水混合物中制备的。在基线、2个月和6个月时记录临床参数[改良龈沟出血指数、菌斑指数、探诊深度（PD）和牙周附着水平（PAL）]，而在基线和6个月时记录影像学参数。使用图像分析软件在标准化X线片上计算基线和6个月时的缺损填充情况。
在2个月和6个月时，阿仑膦酸盐组的平均PD降低和平均PAL增加均高于安慰剂组。此外，与安慰剂组（2.5±0.93%）相比，阿仑膦酸盐组的平均骨填充百分比显著更高（41.05±11.40%）。
本研究结果表明，与安慰剂凝胶相比，1%阿仑膦酸盐在吸烟者慢性牙周炎中可显著增加PD降低、PAL增加，并改善骨填充。因此，1%阿仑膦酸盐与SRP联合使用对吸烟者慢性牙周炎有效。
