Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.
Unit for Thrombosis Research, Department of Public Health, University of Southern Denmark and Department of Clinical Biochemistry, Hospital of South West Jutland, Denmark.
Atherosclerosis. 2017 Oct;265:318-324. doi: 10.1016/j.atherosclerosis.2017.06.923. Epub 2017 Jun 28.
Physical inactivity is linked to low-grade inflammation, endothelial dysfunction and cardiovascular disease. We aimed to determine effects of active commuting and leisure time exercise on markers of low-grade inflammation and endothelial function in overweight and obese women and men.
We randomized 130 younger (20-45 years), physically inactive, healthy, overweight and obese (BMI: 25-35 kg/m) women and men recruited from the Copenhagen area, Denmark, to either 6 months of habitual lifestyle (CON, n = 18), active commuting (BIKE, n = 35), or leisure time exercise of moderate (MOD, ∼50% VOpeak, n = 39) or vigorous intensity (VIG, ∼70% VOpeak, n = 38). Fasting blood samples were collected at baseline, 3, and 6 months and analyzed for concentrations of C-reactive protein (CRP), fibrinogen, von Willebrand factor (vWF), tissue-type plasminogen activator (t-PA), and plasminogen activator inhibitor type 1 (PAI-1), and 90 participants (CON, n = 16; BIKE, n = 19; MOD, n = 31, VIG, n = 24) were included in a per-protocol analysis.
We observed lower concentrations of CRP in MOD compared with CON at 6 months (p = 0.013) and within-group decreases in CRP in BIKE (3 months: p = 0.045) and MOD (3 months: p = 0.061; 6 months: p = 0.038) corresponding to a 30% decrease in BIKE and 19% in MOD from baseline till 6 months. No effects of exercise were observed on fibrinogen, vWF, t-PA, PAI-1 or the t-PA/PAI-1 ratio within or between groups.
Our findings suggest an anti-inflammatory effect of active commuting and moderate, but not vigorous, intensity leisure time exercise, but no alterations in endothelial function during 6 months of intervention.
身体活动不足与低度炎症、内皮功能障碍和心血管疾病有关。我们旨在确定积极通勤和休闲时间运动对超重和肥胖女性和男性低度炎症和内皮功能标志物的影响。
我们随机招募了 130 名来自丹麦哥本哈根地区的年轻（20-45 岁）、身体活动不足、健康、超重和肥胖（BMI：25-35kg/m²）的女性和男性，他们习惯生活方式（CON，n=18）、积极通勤（BIKE，n=35）或休闲时间中等强度（MOD，约 50%VOpeak，n=39）或剧烈强度（VIG，约 70%VOpeak，n=38）运动。在基线、3 个月和 6 个月时采集空腹血样，分析 C 反应蛋白（CRP）、纤维蛋白原、血管性血友病因子（vWF）、组织型纤溶酶原激活物（t-PA）和纤溶酶原激活物抑制剂 1（PAI-1）的浓度，90 名参与者（CON，n=16；BIKE，n=19；MOD，n=31，VIG，n=24）纳入方案分析。
我们观察到，与 CON 相比，MOD 在 6 个月时 CRP 浓度较低（p=0.013），BIKE（3 个月：p=0.045）和 MOD（3 个月：p=0.061；6 个月：p=0.038）组内 CRP 浓度下降，相应的 BIKE 和 MOD 从基线到 6 个月时分别下降了 30%和 19%。运动对纤维蛋白原、vWF、t-PA、PAI-1 或 t-PA/PAI-1 比值均无影响，无论是组内还是组间。
我们的研究结果表明，积极通勤和中等强度但不是剧烈强度的休闲时间运动具有抗炎作用，但在 6 个月的干预期间，内皮功能没有变化。
