所有石棉相关疾病死亡的危险因素：竞争风险分析。
Risk Factors of Mortality from All Asbestos-Related Diseases: A Competing Risk Analysis.
机构信息
Catalan Health Institute (ICS), Division of Primary Health Care, Department of Health, Barcelona, Catalonia, Spain.
Primary Care Research Institute (IDIAP Jordi Gol) and Research Associate, Autonomous University of Barcelona (UAB), Cerdanyola del Vallès, Spain.
出版信息
Can Respir J. 2017;2017:9015914. doi: 10.1155/2017/9015914. Epub 2017 Jun 7.
BACKGROUND
The mortality from all malignant and nonmalignant asbestos-related diseases remains unknown. The authors assessed the incidence and risk factors for all asbestos-related deaths.
METHODS
The sample included 544 patients from an asbestos-exposed community in the area of Barcelona (Spain), between Jan 1, 1970, and Dec 31, 2006. Competing risk regression through a subdistribution hazard analysis was used to estimate risk factors for the outcomes.
RESULTS
Asbestos-related deaths were observed in 167 (30.7%) patients and 57.5% of these deaths were caused by some type of mesothelioma. The incidence rate after diagnosis was 3,600 per 100,000 person-years. In 7.5% of patients death was non-asbestos-related, while pleural and peritoneal mesothelioma were identified in 87 (16.0%) and 18 (3.3%) patients, respectively.
CONCLUSIONS
Age, sex, household exposure, cumulative nonmalignant asbestos-related disease, and single malignant pathology were identified as risk factors for asbestos-related death. These findings suggest the need to develop a preventive approach to the community and to improve the clinical follow-up process of these patients.
背景
所有与石棉相关的恶性和非恶性疾病的死亡率仍不清楚。作者评估了所有与石棉相关的死亡的发生率和危险因素。
方法
该样本包括 1970 年 1 月 1 日至 2006 年 12 月 31 日期间巴塞罗那地区一个暴露于石棉的社区的 544 名患者。通过亚分布风险分析的竞争风险回归用于估计结局的危险因素。
结果
在 167 名（30.7%）患者中观察到与石棉相关的死亡，其中 57.5%的死亡是由某种类型的间皮瘤引起的。诊断后的发病率为每 100,000 人年 3,600 例。在 7.5%的患者中，死亡与石棉无关，而胸膜间皮瘤和腹膜间皮瘤分别在 87 名（16.0%）和 18 名（3.3%）患者中发现。
结论
年龄、性别、家庭暴露、累积非恶性石棉相关疾病和单一恶性病理学被确定为与石棉相关死亡的危险因素。这些发现表明有必要为社区制定预防措施，并改善这些患者的临床随访过程。
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