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病毒性心肌炎患者外周血白细胞介素-35和CD4EBI3 T细胞显著减少，它们与血浆白细胞介素-17和肌钙蛋白I水平升高呈负相关。

Significant reduction of peripheral blood interleukin-35 and CD4EBI3 T cells, which are negatively correlated with an increase in the plasma IL-17 and cTnI level, in viral myocarditis patients.

作者信息

Ouyang Han, Xiang Li, Chen Jianchang, Xu Weiting, Jiao Yang, Shen Huaying

机构信息

Department of Nephrology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Department of Cardiology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

出版信息

Cent Eur J Immunol. 2017;42(1):91-96. doi: 10.5114/ceji.2016.65892. Epub 2017 May 8.

DOI:10.5114/ceji.2016.65892
PMID:28680336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5470605/
Abstract

INTRODUCTION

Viral myocarditis (VMC) has become an increasingly common heart disease that endangers human health. In the present study, the plasma interleukin-35 (IL-35) level and the percentage of CD4EBI3 T cells in VMC patients were detected to investigate the significance of changes in these parameters in the plasma of VMC patients and their association with the disease.

MATERIAL AND METHODS

ELISA was performed to detect the plasma IL-35 level and the percentage of peripheral blood CD4EBI3 T cells in 40 VMC patients and in 20 healthy individuals. Moreover, the plasma IL-17 levels in the VMC patients and in the healthy individuals were detected using an ELISA, and the cardiac Troponin-I (cTnI) levels were detected using a chemiluminescent microparticle immunoassay to compare the differences in the groups.

RESULTS

Plasma IL-35 level and the percentage of CD4 EBI3 T cells in acute phase VMC patients was lower than that in the healthy control group and the convalescent phase VMC patients. Additionally, the plasma IL-35 level in the VMC patients exhibited a negative correlation with the levels of cTnI and IL-17. The percentage of CD4EBI3 T cells also showed a negative correlation with the levels of cTnI and IL-17.

CONCLUSIONS

The plasma IL-35 level and the percentage of CD4EBI3 T cells in VMC patients was reduced, and the amount of the decrease was associated with the severity of the disease. These results suggest that IL-35 and CD4EBI3 T might play important roles in the progression of VMC and could be used as indictors of the disease.

摘要

引言

病毒性心肌炎（VMC）已成为一种日益常见的危害人类健康的心脏病。在本研究中，检测了VMC患者血浆白细胞介素-35（IL-35）水平和CD4EBI3 T细胞百分比，以探讨这些参数在VMC患者血浆中的变化意义及其与疾病的关联。

材料与方法

采用酶联免疫吸附测定（ELISA）法检测40例VMC患者和20例健康个体血浆中IL-35水平及外周血CD4EBI3 T细胞百分比。此外，采用ELISA法检测VMC患者和健康个体血浆中IL-17水平，采用化学发光微粒子免疫分析法检测心肌肌钙蛋白I（cTnI）水平，以比较各组差异。

结果

急性期VMC患者血浆IL-35水平和CD4EBI3 T细胞百分比低于健康对照组和恢复期VMC患者。此外，VMC患者血浆IL-35水平与cTnI和IL-17水平呈负相关。CD4EBI3 T细胞百分比也与cTnI和IL-17水平呈负相关。

结论

VMC患者血浆IL-35水平和CD4EBI3 T细胞百分比降低，降低幅度与疾病严重程度相关。这些结果表明，IL-35和CD4EBI3 T可能在VMC进展中起重要作用，可作为该疾病的指标。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed3e/5470605/cd196f7b7876/CEJI-42-29487-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed3e/5470605/71cf4eb192de/CEJI-42-29487-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed3e/5470605/473eaeb11d1a/CEJI-42-29487-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed3e/5470605/7718f4592851/CEJI-42-29487-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed3e/5470605/5463f7ca071c/CEJI-42-29487-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed3e/5470605/cd196f7b7876/CEJI-42-29487-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed3e/5470605/71cf4eb192de/CEJI-42-29487-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed3e/5470605/473eaeb11d1a/CEJI-42-29487-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed3e/5470605/7718f4592851/CEJI-42-29487-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed3e/5470605/5463f7ca071c/CEJI-42-29487-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed3e/5470605/cd196f7b7876/CEJI-42-29487-g005.jpg

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