Erbayraktar Zubeyde, Turan Evlice Ahmet, Yilmaz Gokhan, Yazici Canan, Yener Gorsev, Ulusu Nuriye Nuray
Dokuz Eylul University, Faculty of Medicine, Department of Biochemistry, Izmir.
Cukurova University, Faculty of Medicine, Department of Neurology, Adana.
J Med Biochem. 2017 Jan 25;36(1):54-61. doi: 10.1515/jomb-2016-0028. eCollection 2017 Jan.
Alzheimer's disease (AD) is a severe multifactorial neurodegenerative proteopathy associated with advanced age. Discrepancies in the renal function of these patients compared to geriatric patients with dementia have rarely been reported. In this study, we aimed to disclose the importance of associated renal changes for the pathogenesis of AD.
Patients with AD (n=107) and geriatric patients with dementia and without dementia (n=124) (231 patients in total) from Dokuz Eylul and Cukurova University Hospitals were enrolled in the study. We measured serum Na, K, Cl, Ca, BUN, creatinine, total protein levels and MDRD [eGFR] in all groups.
From Izmir Center, the first study arm consisted of patients with AD dementia (n=74), and the second arm included geriatric patients with dementia (n=79). From Adana, 78 patients were recruited to the study, of which 33 were with AD and 45 were geriatric patients without dementia. When we analyzed comparatively the AD and geriatric dementia patients study arms, a statistically significant difference was observed both in the median age (p<0.001), as well as in the biochemical parameters from Izmir Center: Na (p<0.001), K (p<0.001), Cl (p<0.05), Ca (p<0.001), BUN (p<0.05), creatinine (p<0.001), total protein (p<0.001) and MDRD [eGFR] (p<0.001). However, these were not significantly different between AD and geriatric patients without dementia in the Adana group.
Our results indicate that renal function is prone to alterations in different age groups of patients with AD. However, there is no conclusive evidence that renal function is one of the risk factors in AD.
阿尔茨海默病（AD）是一种与高龄相关的严重多因素神经退行性蛋白病。与患有痴呆症的老年患者相比，这些患者的肾功能差异鲜有报道。在本研究中，我们旨在揭示相关肾脏变化在AD发病机制中的重要性。
来自多库兹艾吕尔大学和库库罗瓦大学医院的AD患者（n = 107）以及患有和未患有痴呆症的老年患者（n = 124）（共231名患者）被纳入研究。我们测量了所有组的血清钠、钾、氯、钙、尿素氮、肌酐、总蛋白水平和MDRD [估算肾小球滤过率（eGFR）]。
来自伊兹密尔中心，第一个研究组由AD痴呆患者（n = 74）组成，第二个组包括患有痴呆症的老年患者（n = 79）。来自阿达纳的78名患者被纳入研究，其中33名患有AD，45名是未患有痴呆症的老年患者。当我们比较分析AD和老年痴呆患者研究组时，在中位年龄（p < 0.001）以及来自伊兹密尔中心的生化参数方面均观察到统计学显著差异：钠（p < 0.001）、钾（p < 0.001）、氯（p < 0.05）、钙（p < 0.001）、尿素氮（p < 0.05）、肌酐（p < 0.001）、总蛋白（p < 0.001）和MDRD [eGFR]（p < 0.001）。然而，在阿达纳组中，AD患者与未患有痴呆症的老年患者之间这些指标并无显著差异。
我们的结果表明，AD患者的不同年龄组肾功能易于发生改变。然而，没有确凿证据表明肾功能是AD的危险因素之一。
