Turk J Med Sci. 2015;45(5):1159-66. doi: 10.3906/sag-1406-136.
BACKGROUND/AIM: Alzheimer disease, a common proteopathy of advanced age, is characterized by cortical atrophy, neuron degeneration, neuronal loss, and accumulation of extracellular amyloid β plaques. We aimed to investigate serum vitamin B12 and folic acid levels in Alzheimer disease and other dementia patients, as a potential screening test to detect presymptomatic Alzheimer disease in Turkish patients.
We evaluated folic acid and vitamin B12 levels in Alzheimer disease patients as well as in other dementia and geriatric patients from Ankara, Dokuz Eylül, and Çukurova university hospitals; 290 female and male geriatric subjects were enrolled. Vitamin B12 and folic acid levels were measured using Roche E170 and Beckman Coulter DXI 800 immunoassays (chemiluminescence) according to the manufacturers' guideline in all centers.
We evaluated the results of folic acid and vitamin B12 in Alzheimer disease, other dementias and geriatric patients. No significant difference between the groups regarding the routine control of biochemical parameters was observed.
Currently, serum folic and vitamin B12 levels are not diagnostically reliable tests for screening presymptomatic Alzheimer disease. However, the results may statistically be significant if we increase the sample size.
背景/目的：阿尔茨海默病是一种常见的高龄期蛋白病变，其特征为皮质萎缩、神经元退化、神经元丧失以及细胞外淀粉样 β 斑块的积累。我们旨在研究阿尔茨海默病和其他痴呆症患者的血清维生素 B12 和叶酸水平，作为一种潜在的筛查试验，以检测土耳其患者的无症状性阿尔茨海默病。
我们评估了安卡拉、多乌泽耶尔和恰武什奥卢大学医院的阿尔茨海默病患者以及其他痴呆症和老年患者的叶酸和维生素 B12 水平；共纳入 290 名男女老年受试者。所有中心均根据制造商的指南，使用罗氏 E170 和贝克曼库尔特 DXI 800 免疫分析（化学发光）测定维生素 B12 和叶酸水平。
我们评估了叶酸和维生素 B12 在阿尔茨海默病、其他痴呆症和老年患者中的结果。各组之间关于生化参数的常规控制无显著差异。
目前，血清叶酸和维生素 B12 水平不是用于筛查无症状性阿尔茨海默病的可靠诊断试验。但是，如果我们增加样本量，结果可能具有统计学意义。
