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重型β地中海贫血脾切除患者的巨细胞病毒感染：免疫功能正常还是免疫抑制？

Cytomegalovirus infection in a splenectomized with -thalassemia major: immunocompetent or immunosuppressed?

作者信息

Liatsos George D, Pirounaki Maria, Lazareva Angelina, Kikezou Georgia, Dourakis Spyridon P

机构信息

nd2nd Academic Department of Internal Medicine Medical School Hippokratio General Hospital National and Kapodistrian Athens University Athens Greece.

出版信息

Clin Case Rep. 2017 May 16;5(7):1063-1066. doi: 10.1002/ccr3.1001. eCollection 2017 Jul.

DOI:10.1002/ccr3.1001
PMID:28680595
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5494393/
Abstract

We should possibly revise our knowledge about risk assessment of splenectomized individuals with -thalassemia major. Besides their known risk of certain bacterial infection, they might be also in a risk of life-threatening primary cytomegalovirus (CMV) infection and end-, multi-organ disease, in the context of their immunosuppression status. Prompt and appropriate treatment initiation can be life saving.

摘要

我们或许应该修正对重型β地中海贫血脾切除患者风险评估的认识。除了已知的某些细菌感染风险外，鉴于其免疫抑制状态，他们还可能面临危及生命的原发性巨细胞病毒（CMV）感染以及终末期多器官疾病的风险。及时且恰当的治疗启动可能挽救生命。

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引用本文的文献

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Medicine (Baltimore). 2019 Oct;98(43):e17698. doi: 10.1097/MD.0000000000017698.

本文引用的文献

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Up-regulation of NKG2A inhibitory receptor on circulating NK cells contributes to transfusion-induced immunodepression in patients with β-thalassemia major.循环自然杀伤细胞上NKG2A抑制性受体的上调促成了重型β地中海贫血患者输血诱导的免疫抑制。
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Serum levels of TGFβ, IL-10, IL-17, and IL-23 cytokines in β-thalassemia major patients: the impact of silymarin therapy.重型β地中海贫血患者血清中转化生长因子β、白细胞介素-10、白细胞介素-17和白细胞介素-23细胞因子水平：水飞蓟素治疗的影响
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Spontaneous splenic rupture associated with CMV infection: report of a case and review.巨细胞病毒感染相关的自发性脾破裂：一例报告及文献复习
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