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肾移植后IgA肾病患者的尿道淀粉样变性

Urethral Amyloidosis in a Patient with IgA Nephropathy After Renal Transplant.

作者信息

Ojile Nicholas, Brake Mona

机构信息

Internal Medicine, University of Kansas School of Medicine - Wichita.

出版信息

Cureus. 2017 May 30;9(5):e1296. doi: 10.7759/cureus.1296.

DOI:10.7759/cureus.1296
PMID:28680784
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5493464/
Abstract

Urethral amyloidosis is a rare condition that can cause hematuria and urinary obstruction symptoms. While there is no established association between immunoglobulin A (IgA) nephropathy and secondary amyloidosis, which is typically found in chronic inflammatory conditions, it is hypothesized that IgA nephropathy may be a systemic condition with inflammatory mediators. We present a case of urethral amyloidosis in a patient with IgA nephropathy who previously received a renal transplant.

摘要

尿道淀粉样变性是一种罕见的疾病，可导致血尿和尿路梗阻症状。虽然免疫球蛋白A（IgA）肾病与继发性淀粉样变性之间尚无明确关联，继发性淀粉样变性通常见于慢性炎症性疾病，但据推测IgA肾病可能是一种伴有炎症介质的全身性疾病。我们报告一例患有IgA肾病且此前接受过肾移植的患者发生尿道淀粉样变性的病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b141/5493464/ce094e399e0e/cureus-0009-00000001296-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b141/5493464/c61b6d573f0d/cureus-0009-00000001296-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b141/5493464/ce094e399e0e/cureus-0009-00000001296-i02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b141/5493464/c61b6d573f0d/cureus-0009-00000001296-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b141/5493464/ce094e399e0e/cureus-0009-00000001296-i02.jpg

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引用本文的文献

1
Progress in Pathogenesis of Immunoglobin A Nephropathy.免疫球蛋白A肾病发病机制的研究进展
Cureus. 2020 Jun 23;12(6):e8789. doi: 10.7759/cureus.8789.

本文引用的文献

1
Systemic AA amyloidosis: epidemiology, diagnosis, and management.系统性 AA 淀粉样变：流行病学、诊断与治疗。
Clin Epidemiol. 2014 Oct 29;6:369-77. doi: 10.2147/CLEP.S39981. eCollection 2014.
2
IgA nephropathy.IgA肾病
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Natural history and outcome in systemic AA amyloidosis.系统性AA型淀粉样变性的自然病史及预后
N Engl J Med. 2007 Jun 7;356(23):2361-71. doi: 10.1056/NEJMoa070265.
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IgA nephropathy.IgA肾病
J Am Soc Nephrol. 2005 Jul;16(7):2088-97. doi: 10.1681/ASN.2005020134. Epub 2005 Jun 1.
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A case of amyloid of the urethra and review of this rare diagnosis, its natural history and management, with reference to the literature.一例尿道淀粉样变病例，并结合文献对这一罕见诊断、其自然病史及治疗进行综述。
Scand J Urol Nephrol. 2002;36(6):481-6. doi: 10.1080/003655902762467675.
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Amyloidosis presenting in the urethra.尿道淀粉样变性病
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Localized amyloidosis of the urethra: diagnostic implications and management.尿道局限性淀粉样变性：诊断意义与处理
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