静脉吸毒者门诊胃肠外抗生素治疗计划失败的相关风险因素
Risk Factors Associated With Outpatient Parenteral Antibiotic Therapy Program Failure Among Intravenous Drug Users.
作者信息
Buehrle Deanna J, Shields Ryan K, Shah Neel, Shoff Christopher, Sheridan Kathleen
机构信息
University of Pittsburgh, Pennsylvania.
出版信息
Open Forum Infect Dis. 2017 May 23;4(3):ofx102. doi: 10.1093/ofid/ofx102. eCollection 2017 Summer.
Abstract
Sixty-one percent of intravenous drug users (IVDUs) who received outpatient parenteral antibiotic therapy (OPAT) failed treatment. Hospital readmission and adverse drug reactions occurred in 25%. By multivariate analysis, time since last IVDU was associated with failure ( = .04). Intravenous drug users requiring OPAT are at high risk for failure; additional studies are needed to explore alternatives.
摘要
接受门诊胃肠外抗生素治疗（OPAT）的静脉注射吸毒者（IVDUs）中有61%治疗失败。25%的患者出现医院再入院和药物不良反应。多因素分析显示，距上次静脉注射吸毒的时间与治疗失败相关（P = .04）。需要接受OPAT的静脉注射吸毒者治疗失败风险很高；需要开展更多研究来探索替代方案。
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