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Nationwide increase in hospitalizations for heroin-related soft tissue infections: Associations with structural market conditions.全国范围内与海洛因相关的软组织感染住院人数增加：与结构性市场状况的关联。
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Hospitalizations Related To Opioid Abuse/Dependence And Associated Serious Infections Increased Sharply, 2002-12.2002年至2012年期间，与阿片类药物滥用/依赖相关的住院治疗及相关严重感染大幅增加。
Health Aff (Millwood). 2016 May 1;35(5):832-7. doi: 10.1377/hlthaff.2015.1424.
3
Adverse Events Lead to Drug Discontinuation More Commonly among Patients Who Receive Nafcillin than among Those Who Receive Oxacillin.与接受苯唑西林的患者相比，接受萘夫西林的患者因不良事件而停药的情况更为常见。
Antimicrob Agents Chemother. 2016 Apr 22;60(5):3090-5. doi: 10.1128/AAC.03122-15. Print 2016 May.
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Outcomes and Pharmacoeconomic Analysis of a Home Intravenous Antibiotic Infusion Program in Veterans.退伍军人家庭静脉抗生素输注项目的结果及药物经济学分析
Clin Ther. 2015 Nov 1;37(11):2527-35. doi: 10.1016/j.clinthera.2015.09.009. Epub 2015 Oct 21.
5
The history and evolution of outpatient parenteral antibiotic therapy (OPAT).门诊肠外抗生素治疗（OPAT）的历史和演变。
Int J Antimicrob Agents. 2015 Sep;46(3):307-12. doi: 10.1016/j.ijantimicag.2015.07.001. Epub 2015 Jul 17.
6
Surgical treatment of infective endocarditis in active intravenous drug users: a justified procedure?活跃静脉吸毒者感染性心内膜炎的外科治疗：一种合理的手术吗？
J Cardiothorac Surg. 2014 Mar 24;9:58. doi: 10.1186/1749-8090-9-58.
7
Outpatient parenteral antimicrobial therapy at large Veterans Administration medical center.大型退伍军人管理局医疗中心的门诊胃肠外抗菌治疗。
Am J Manag Care. 2013 Sep;19(9):e317-24.
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Adverse events, healthcare interventions and healthcare utilization during home infusion therapy with daptomycin and vancomycin: a propensity score-matched cohort study.达托霉素和万古霉素家庭输注治疗期间的不良事件、医疗保健干预措施及医疗保健利用情况：一项倾向评分匹配队列研究
J Antimicrob Chemother. 2014 May;69(5):1407-15. doi: 10.1093/jac/dkt512. Epub 2014 Jan 6.
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Factors associated with outcome and duration of therapy in outpatient parenteral antibiotic therapy (OPAT) patients with skin and soft-tissue infections.门诊静脉用抗生素治疗（OPAT）皮肤软组织感染患者的结局和治疗持续时间的相关因素。
Int J Antimicrob Agents. 2011 Sep;38(3):243-8. doi: 10.1016/j.ijantimicag.2011.05.008. Epub 2011 Jul 7.
10
Safe and successful treatment of intravenous drug users with a peripherally inserted central catheter in an outpatient parenteral antibiotic treatment service.在门诊静脉用抗生素治疗服务中，为静脉注射吸毒者使用外周置入中心静脉导管进行安全且成功的治疗。
J Antimicrob Chemother. 2010 Dec;65(12):2641-4. doi: 10.1093/jac/dkq355. Epub 2010 Sep 23.

静脉吸毒者门诊胃肠外抗生素治疗计划失败的相关风险因素

Risk Factors Associated With Outpatient Parenteral Antibiotic Therapy Program Failure Among Intravenous Drug Users.

作者信息

Buehrle Deanna J, Shields Ryan K, Shah Neel, Shoff Christopher, Sheridan Kathleen

机构信息

University of Pittsburgh, Pennsylvania.

出版信息

Open Forum Infect Dis. 2017 May 23;4(3):ofx102. doi: 10.1093/ofid/ofx102. eCollection 2017 Summer.

DOI:10.1093/ofid/ofx102
PMID:28680904
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5493937/
Abstract

Sixty-one percent of intravenous drug users (IVDUs) who received outpatient parenteral antibiotic therapy (OPAT) failed treatment. Hospital readmission and adverse drug reactions occurred in 25%. By multivariate analysis, time since last IVDU was associated with failure ( = .04). Intravenous drug users requiring OPAT are at high risk for failure; additional studies are needed to explore alternatives.

摘要

接受门诊胃肠外抗生素治疗（OPAT）的静脉注射吸毒者（IVDUs）中有61%治疗失败。25%的患者出现医院再入院和药物不良反应。多因素分析显示，距上次静脉注射吸毒的时间与治疗失败相关（P = .04）。需要接受OPAT的静脉注射吸毒者治疗失败风险很高；需要开展更多研究来探索替代方案。