患有口腔念珠菌病的HIV-1患者血浆中转化生长因子β的水平。
Plasma levels of Transforming Growth Factor Beta in HIV-1 patients with oral candidiasis.
作者信息
Izadi A, Asadikaram G, Nakhaee N, Hadizadeh S, Ayatollahi Mousavi A
机构信息
Department of Medical Mycology and Parasitology,School of Medicine,Kerman University of Medical Sciences,Kerman,Iran.
Physiology Research Center,Institute of Neuropharmacology and Department of Biochemistry,School of Medicine,Kerman University of Medical Sciences,Kerman,Iran.
出版信息
Curr Med Mycol. 2015 Mar;1(1):22-25. doi: 10.18869/acadpub.cmm.1.1.22.
BACKGROUND AND PURPOSE
TGF-β is a potent regulator and suppressor of the immune system and overproduction of this cytokine may contribute to immunosuppression in HIV-infected patients. Increasing population of immunosuppressed patients has resulted in increasingly frequent of fungal infections, including oral candidiasis. The aim of this study was to evaluate the plasma levels of TGF-β under conditions.
MATERIALS AND METHODS
Seventy- two samples were obtained from the oral cavities of HIV-positive Iranian patients and cultured on Sabouraud's dextrose agar and CHROMagar. Also blood samples were obtained to assess TGF-β levels using ELISA technique.
RESULTS
Thirty-three out of 72 oral samples yielded isolates, in 14 and non- in 19.Fungal infection decreased significantly more TGF-β level than non-fungal infection also HIV negative were significantly more TGF-β than HIV positive.
CONCLUSION
Our findings suggest a significant interaction between fungal infection and HIV on expression of Transforming Growth Factor Beta
背景与目的
转化生长因子-β（TGF-β）是免疫系统的一种强效调节剂和抑制剂，这种细胞因子的过度产生可能导致HIV感染患者的免疫抑制。免疫抑制患者数量的增加导致真菌感染（包括口腔念珠菌病）越来越频繁。本研究的目的是评估在特定条件下TGF-β的血浆水平。
材料与方法
从伊朗HIV阳性患者的口腔中获取72份样本，接种在沙氏葡萄糖琼脂和科玛嘉显色培养基上培养。同时采集血液样本，使用酶联免疫吸附测定（ELISA）技术评估TGF-β水平。
结果
72份口腔样本中有33份培养出分离株，其中14份为真菌感染，19份为非真菌感染。真菌感染比非真菌感染更显著地降低了TGF-β水平，而且HIV阴性者的TGF-β水平显著高于HIV阳性者。
结论
我们的研究结果表明真菌感染与HIV在转化生长因子β的表达上存在显著相互作用
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