Departments of Surgery and Microbiology and Immunology, Center for Vascular and Inflammatory Disease, University of Maryland School of Medicine, Baltimore, MD, USA.
Departments of Surgery and Microbiology and Immunology, Center for Vascular and Inflammatory Disease, University of Maryland School of Medicine, Baltimore, MD, USA.
Trends Immunol. 2017 Nov;38(11):858-871. doi: 10.1016/j.it.2017.06.002. Epub 2017 Jul 3.
Laminins are trimeric proteins that are major components of the basement membranes that separate endothelia and epithelia from the underlying tissue. Sixteen laminin isoforms have been described, each with distinct tissue expression patterns and functions. While laminins have a critical structural role, recent evidence also indicates that they also impact the migration and functions of immune cells. Laminins are differentially expressed upon immunity or tolerance and orientate the immune response. This review will summarize the structure of laminins, the modulation of their expression, and their interactions with the immune system. Finally, the role of the laminins in autoimmune diseases and transplantation will be discussed.
层粘连蛋白是三聚体蛋白，是将内皮细胞和上皮细胞与下面的组织分开的基底膜的主要成分。已经描述了十六种层粘连蛋白同工型，每种都具有独特的组织表达模式和功能。虽然层粘连蛋白具有关键的结构作用，但最近的证据也表明它们还影响免疫细胞的迁移和功能。在免疫或耐受时，层粘连蛋白的表达会发生差异，并使免疫反应定向。这篇综述将总结层粘连蛋白的结构、其表达的调节以及与免疫系统的相互作用。最后，将讨论层粘连蛋白在自身免疫性疾病和移植中的作用。
