Deutsch Julia, Jolliffe Colette, Archer Emma, Leece Elizabeth A
Animal Health Trust, Kentford, Newmarket, UK.
Animal Health Trust, Kentford, Newmarket, UK.
Vet Anaesth Analg. 2017 Jul;44(4):794-802. doi: 10.1016/j.vaa.2016.05.014. Epub 2017 Mar 6.
To assess quality of sedation following intramuscular (IM) injection of two doses of alfaxalone in combination with butorphanol in cats.
Prospective, randomized, 'blinded' clinical study.
A total of 38 cats undergoing diagnostic imaging or noninvasive procedures.
Cats were allocated randomly to be administered butorphanol 0.2 mg kg combined with alfaxalone 2 mg kg (group AB2) or 5 mg kg (group AB5) IM. If sedation was inadequate, alfaxalone 2 mg kg IM was administered and cats were excluded from further analysis. Temperament [1 (friendly) to 5 (aggressive)], response to injection, sedation score at 2, 6, 8, 15, 20, 30, 40, 50 and 60 minutes, overall sedation quality scored after data collection [1 (excellent) to 4 (inadequate)] and recovery quality were assessed. Heart rate (HR), respiratory rate (f) and arterial haemoglobin saturation (SpO) were recorded every 5 minutes. Groups were compared using t tests and Mann-Whitney U tests. Sedation was analysed using two-way anova, and additional alfaxalone using Fisher's exact test (p < 0.05).
Groups were similar for sex, age, body mass and response to injection. Temperament score was lower in group AB2 [2 (1-3)] compared to AB5 [3 (1-5)] (p = 0.006). Group AB5 had better sedation at 6, 8, 20 and 30 minutes and overall sedation quality was better in AB5 [1 (1-3)], compared to AB2 [3 (1-4)] (p = 0.0001). Additional alfaxalone was required for 11 cats in AB2 and two in AB5 (p = 0.005). Recovery quality, HR, f and SpO were similar. Seven cats required oxygen supplementation. Complete recovery times were shorter in AB2 (81.8 ± 24.3 versus 126.6 ± 33.3 minutes; p = 0.009). Twitching was the most common adverse event.
In combination with butorphanol, IM alfaxalone at 5 mg kg provided better quality sedation than 2 mg kg. Monitoring of SpO is recommended.
评估猫肌肉注射两剂阿法沙龙与布托啡诺联合使用后的镇静质量。
前瞻性、随机、“盲法”临床研究。
总共38只接受诊断性成像或非侵入性检查的猫。
将猫随机分为两组，分别肌肉注射0.2mg/kg布托啡诺与2mg/kg阿法沙龙（AB2组）或5mg/kg阿法沙龙（AB5组）。如果镇静效果不佳，则肌肉注射2mg/kg阿法沙龙，这些猫被排除在进一步分析之外。评估猫的性情[1（友好）至5（攻击性）]、对注射的反应、在2、6、8、15、20、30、40、50和60分钟时的镇静评分、数据收集后评估的总体镇静质量[1（优秀）至4（不足）]以及恢复质量。每5分钟记录心率（HR）、呼吸频率（f）和动脉血红蛋白饱和度（SpO）。使用t检验和曼-惠特尼U检验对两组进行比较。使用双向方差分析分析镇静情况，使用费舍尔精确检验分析额外使用阿法沙龙的情况（p<0.05）。
两组在性别、年龄、体重和对注射的反应方面相似。AB2组的性情评分[2（1 - 3）]低于AB5组[3（1 - 5）]（p = 0.006）。AB5组在6、8、20和30分钟时镇静效果更好，与AB2组[3（1 - 4）]相比，AB5组的总体镇静质量更好[1（1 - 3）]（p = 0.0001）。AB2组有11只猫需要额外注射阿法沙龙，AB5组有2只猫需要额外注射（p = 0.005）。恢复质量、HR、f和SpO相似。7只猫需要补充氧气。AB2组的完全恢复时间更短（81.8±24.3分钟对126.6±33.3分钟；p = 0.009）。抽搐是最常见的不良事件。
与布托啡诺联合使用时，5mg/kg肌肉注射阿法沙龙比2mg/kg提供更好的镇静质量。建议监测SpO。
