Department of Orthopedics, Peking University China-Japan Friendship School of Clinical Medicine, 2 Yinghuadong Road, Chaoyang District, Beijing, 100029, China.
Centre for Osteonecrosis and Joint-Preserving & Reconstruction, Department of Orthopedic Surgery, Beijing Key Laboratory of Arthritic and Rheumatic Diseases, China-Japan Friendship Hospital, National Health and Family Planning Commission of the People's Republic of China, Beijing, 100029, China.
Osteoporos Int. 2017 Oct;28(10):2945-2953. doi: 10.1007/s00198-017-4136-7. Epub 2017 Jul 6.
It has been proved that extracorporeal shock wave therapy (ESWT) could promote new bone formation. Therefore, we designed an experiment to test the efficiency of ESWT on BMD in postmenopausal osteoporotic patients. The results showed that ESWT could effectively improve the local bone mass of the treated bone area within a short duration.
This study evaluated the short-term effectiveness of extracorporeal shock wave therapy (ESWT) on bone mineral density (BMD).
A total of 64 postmenopausal osteoporotic patients were recruited and randomized into 3 groups in 2015. Groups A (n = 20) and B (n = 21) patients received a single-session of low- or high-energy flux density (EFD) ESWT in the left hip, respectively, whereas group C (n = 23) patients served as controls without the ESWT treatment. All patients self-administered alendronate sodium tablets orally for a year. The BMD of the lumbar spine (L2-L4), femoral neck, great tuberosity, and total left hip was measured before ESWT treatment and at 3, 6, and 12 months using dual energy X-ray absorptiometry (DEXA).
At 12 months, the lumbar spine, femoral neck, great tuberosity, and total left hip BMD in all patients had increased (p < 0.01). The increase in lumbar spine BMD in group A patients was higher than that in group B patients (p = 0.03); other between-group differences were not observed (p = 0.73, group A vs. C; p = 0.06, group B vs. C). The femoral neck, great tuberosity, and total left hip BMD increases in group B patients were higher than that in either group A or C (p < 0.01, group B vs. A; p < 0.01, group A vs. C).
This study showed that ESWT could efficiently improve the local BMD; relatively, the high dosage was effective.
本研究评估了体外冲击波疗法（ESWT）对骨密度（BMD）的短期疗效。
2015 年，共招募了 64 名绝经后骨质疏松症患者，并将其随机分为 3 组。A 组（n=20）和 B 组（n=21）患者分别接受单次低能或高能通量密度（EFD）ESWT 左髋治疗，而 C 组（n=23）患者作为对照组未接受 ESWT 治疗。所有患者均口服阿仑膦酸钠片治疗 1 年。治疗前及治疗后 3、6、12 个月采用双能 X 线吸收仪（DEXA）测量腰椎（L2-L4）、股骨颈、大转子和全左髋的 BMD。
12 个月时，所有患者的腰椎、股骨颈、大转子和全左髋 BMD 均增加（p<0.01）。A 组患者腰椎 BMD 增加高于 B 组（p=0.03）；其他组间差异无统计学意义（p=0.73，A 组与 C 组比较；p=0.06，B 组与 C 组比较）。B 组患者的股骨颈、大转子和全左髋 BMD 增加均高于 A 组和 C 组（p<0.01，B 组与 A 组比较；p<0.01，A 组与 C 组比较）。
本研究表明，ESWT 可有效提高局部 BMD，相对而言，高剂量更有效。
