Department of Medical Imaging, Ningbo No.2 Hospital, Ningbo, Zhejiang, 315010, China.
Key Laboratory of Magnetic Materials and Devices & Division of Functional Materials and Nanodevices, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo, 315201, China.
Curr Med Chem. 2018;25(25):3001-3016. doi: 10.2174/0929867324666170705144642.
Breast cancer accounts for nearly one in three cancers, and it is the most common cancer diagnosed among women. The death rate of breast cancer is estimated to be 14%. Hence, accurate diagnosis in early stage and effective treatment in any stage are critical for the survival of breast cancer. Mammogram has been the most common technique administered to detect breast cancer. However, the radiation dose from mammogram is harmful to patients. Fortunately, magnetic resonance imaging (MRI) can diagnose breast cancer without any radiation dose, and enhanced MRI can make earlier and differential diagnosis. Therefore, as contrast materials, superparamagnetic iron oxide based nanoprobes (SPIONs) have generated a great deal of attention.
This review covers recent advances in SPIONs as multifunctional theranostic agents.
Besides synthesis and surface modification of SPIONs, passive and active targeted imaging is also discussed. Moreover, a serial of potential therapy for breast cancer is further described, such as photodynamic therapy, photothermal therapy, chemotherapy and magnetic hyperthermia therapy.
Preparation and surface modification of SPIONs is critical for imaging diagnosis of breast cancer and further potential treatment.
乳腺癌占癌症的近三分之一，是女性最常见的癌症。乳腺癌的死亡率估计为 14%。因此，早期准确诊断和任何阶段的有效治疗对乳腺癌的生存至关重要。乳房 X 线照相术是最常用于检测乳腺癌的技术。然而，乳房 X 线照相术的辐射剂量对患者有害。幸运的是，磁共振成像（MRI）可以在没有任何辐射剂量的情况下诊断乳腺癌，增强 MRI 可以更早和更有区别地进行诊断。因此，作为对比剂，超顺磁氧化铁基纳米探针（SPIONs）引起了极大的关注。
本综述涵盖了作为多功能治疗诊断试剂的 SPIONs 的最新进展。
除了 SPIONs 的合成和表面修饰外，还讨论了被动和主动靶向成像。此外，还进一步描述了一系列针对乳腺癌的潜在治疗方法，如光动力疗法、光热疗法、化学疗法和磁热疗。
SPIONs 的制备和表面修饰对于乳腺癌的成像诊断和进一步的潜在治疗至关重要。
