Arentz Susan, Smith Caroline A, Abbott Jason, Fahey Paul, Cheema Birinder S, Bensoussan Alan
National Institute of Complementary Medicine, Western Sydney University, Building 5, Campbelltown Campus, Locked Bag 1797, Penrith, NSW, 2751, Australia.
School of Women's and Children's Health, Level 1, Women's Health Institute, Royal Hospital for Women, University of New South Wales, Barker Street, Randwick, NSW, 2031, Australia.
Phytother Res. 2017 Sep;31(9):1330-1340. doi: 10.1002/ptr.5858. Epub 2017 Jul 7.
Polycystic ovary syndrome (PCOS) is a common, complex reproductive endocrinopathy characterized by menstrual irregularities, hyperandrogenism and polycystic ovaries. Lifestyle modification is a first-line intervention; however, there are barriers to success for this form of self-care, and women often seek adjunct therapies including herbal medicines. This pragmatic, randomized controlled trial, delivered in communities of Australia in overweight women with PCOS, compared the effectiveness and safety of a lifestyle intervention plus herbal medicine against lifestyle alone. All participants were helped to construct a personalized lifestyle plan. The herbal intervention consisted of two tablets. Tablet 1 contained Cinnamomum verum, Glycyrrhiza glabra, Hypericum perforatum and Paeonia lactiflora. Tablet 2 contained Tribulus terrestris. The primary outcome was oligomenorrhoea/amenorrhoea. Secondary outcomes were hormones; anthropometry; quality of life; depression, anxiety and stress; pregnancy; birth outcomes; and safety. One hundred and twenty-two women gave their consent. At 3 months, women in the combination group recorded a reduction in oligomenorrhoea of 32.9% (95% confidence interval 23.3-42.6, p < 0.01) compared with controls, estimated as a large effect (η = 0.11). Other significant improvements were found for body mass index (p < 0.01); insulin (p = 0.02) and luteinizing hormone (p = 0.04); blood pressure (p = 0.01); quality of life (p < 0.01); depression, anxiety and stress (p < 0.01); and pregnancy rates (p = 0.01). This trial provides evidence of improved effectiveness and safety for lifestyle intervention when combined with herbal medicines in women with PCOS. © 2017 The Authors. Phytotherapy Research published by John Wiley & Sons Ltd.
多囊卵巢综合征（PCOS）是一种常见的、复杂的生殖内分泌疾病，其特征为月经不规律、高雄激素血症和多囊卵巢。生活方式改变是一线干预措施；然而，这种自我护理形式存在成功障碍，女性常常寻求包括草药在内的辅助疗法。这项务实的随机对照试验在澳大利亚社区的超重PCOS女性中开展，比较了生活方式干预加草药与单纯生活方式干预的有效性和安全性。所有参与者都得到帮助以制定个性化的生活方式计划。草药干预由两片药组成。药片1含有锡兰肉桂、光果甘草、贯叶连翘和白芍。药片2含有刺蒺藜。主要结局是月经过少/闭经。次要结局包括激素水平；人体测量指标；生活质量；抑郁、焦虑和压力；妊娠；分娩结局；以及安全性。122名女性同意参与。在3个月时，与对照组相比，联合治疗组女性的月经过少减少了32.9%（95%置信区间23.3 - 42.6，p < 0.01），估计为较大效应（η = 0.11）。在体重指数（p < 0.01）；胰岛素（p = 0.02）和促黄体生成素（p = 0.04）；血压（p = 0.01）；生活质量（p < 0.01）；抑郁、焦虑和压力（p < 0.01）；以及妊娠率（p = 0.01）方面也发现了其他显著改善。这项试验为PCOS女性生活方式干预与草药联合使用时有效性和安全性的提高提供了证据。© 2017作者。《植物疗法研究》由约翰·威利父子有限公司出版。
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