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Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.
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The unfolded protein response regulates hepatic autophagy by sXBP1-mediated activation of TFEB.
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Regulation of the Homeostatic Unfolded Protein Response in Diabetic Nephropathy.
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PI 3-kinase regulatory subunits as regulators of the unfolded protein response.
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modulates X-box-binding protein 1 (XBP1) expression during the adaptive phase of the unfolded protein response.
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PDIA4 targets IRE1α/sXBP1 to alleviate NLRP3 inflammasome activation and renal tubular injury in diabetic kidney disease.
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p85α deficiency protects β-cells from endoplasmic reticulum stress-induced apoptosis.
Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):1192-7. doi: 10.1073/pnas.1322564111. Epub 2014 Jan 6.

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The activation of spliced X-box binding protein 1 by isorhynchophylline therapy improves diabetic encephalopathy.
Cell Biol Toxicol. 2023 Dec;39(6):2587-2613. doi: 10.1007/s10565-022-09789-z. Epub 2023 Jan 25.
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Hypercoagulability Impairs Plaque Stability in Diabetes-Induced Atherosclerosis.
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Association between Vitamin D Status and Mortality among Adults with Diabetic Kidney Disease.
J Diabetes Res. 2022 May 9;2022:9632355. doi: 10.1155/2022/9632355. eCollection 2022.
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Regulation of the Homeostatic Unfolded Protein Response in Diabetic Nephropathy.
Pharmaceuticals (Basel). 2022 Mar 25;15(4):401. doi: 10.3390/ph15040401.
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Activated Protein C Ameliorates Diabetic Cardiomyopathy Modulating OTUB1/YB-1/MEF2B Axis.
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2
Proteinases, Their Extracellular Targets, and Inflammatory Signaling.
Pharmacol Rev. 2016 Oct;68(4):1110-1142. doi: 10.1124/pr.115.010991.
3
The emerging role of coagulation proteases in kidney disease.
Nat Rev Nephrol. 2016 Feb;12(2):94-109. doi: 10.1038/nrneph.2015.177. Epub 2015 Nov 23.
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Proteostasis control by the unfolded protein response.
Nat Cell Biol. 2015 Jul;17(7):829-38. doi: 10.1038/ncb3184.
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Activated Protein C Ameliorates Renal Ischemia-Reperfusion Injury by Restricting Y-Box Binding Protein-1 Ubiquitination.
J Am Soc Nephrol. 2015 Nov;26(11):2789-99. doi: 10.1681/ASN.2014080846. Epub 2015 May 26.
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Molecular mechanisms of diabetic kidney disease.
J Clin Invest. 2014 Jun;124(6):2333-40. doi: 10.1172/JCI72271. Epub 2014 Jun 2.
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Activated protein C based therapeutic strategies in chronic diseases.
Thromb Haemost. 2014 Apr 1;111(4):610-7. doi: 10.1160/TH13-11-0967. Epub 2014 Mar 20.
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Unfolded protein response signaling and metabolic diseases.
J Biol Chem. 2014 Jan 17;289(3):1203-11. doi: 10.1074/jbc.R113.534743. Epub 2013 Dec 9.
10
ER stress-induced cell death mechanisms.
Biochim Biophys Acta. 2013 Dec;1833(12):3460-3470. doi: 10.1016/j.bbamcr.2013.06.028. Epub 2013 Jul 10.

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