聚多巴胺包覆的具有超高弛豫率的氧化锰纳米颗粒作为用于磁共振成像引导的协同化学/光热疗法的纳米诊疗剂。
Polydopamine coated manganese oxide nanoparticles with ultrahigh relaxivity as nanotheranostic agents for magnetic resonance imaging guided synergetic chemo-/photothermal therapy.
作者信息
Ding Xing, Liu Jianhua, Li Junqi, Wang Fan, Wang Yinghui, Song Shuyan, Zhang Hongjie
机构信息
State Key Laboratory of Rare Earth Resource Utilization , Changchun Institute of Applied Chemistry , Chinese Academy of Sciences , Changchun 130022 , P. R. China . Email:
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry , College of Chemistry , Jilin University , Changchun 130012 , P. R. China.
出版信息
Chem Sci. 2016 Nov 1;7(11):6695-6700. doi: 10.1039/c6sc01320a. Epub 2016 Jul 6.
Mn-based nanoparticles have been regarded as a new class of probes for magnetic resonance imaging (MRI), but their low relaxivity is the major obstacle for applications . Herein, we designed and constructed a multifunctional nanotheranostic (FA-MnO@PDA@PEG) for MRI guided combinatorial chemo-/photothermal therapy (PTT) for cancer. The ultrahigh relaxivity of 14.47 mM s makes the nanotheranostic an excellent contrast agent for MRI and , and provides comprehensive information for tumor diagnosis. When irradiated with an 808 nm NIR laser, FA-MnO@PDA@PEG exhibits a remarkably improved and synergistic therapeutic effect compared to PTT or chemotherapy alone, providing high therapeutic efficiency and low side effects of drugs. These findings are of great interest and will inspire us to develop highly effective MRI guided synergetic chemo-/photothermal therapy for cancer treatment.
锰基纳米颗粒被视为一类新型的磁共振成像（MRI）探针，但其低弛豫率是应用的主要障碍。在此，我们设计并构建了一种用于MRI引导的癌症联合化学/光热疗法（PTT）的多功能纳米诊疗剂（FA-MnO@PDA@PEG）。14.47 mM s的超高弛豫率使该纳米诊疗剂成为MRI的优良造影剂，并为肿瘤诊断提供全面信息。当用808 nm近红外激光照射时，与单独的PTT或化疗相比，FA-MnO@PDA@PEG表现出显著改善的协同治疗效果，提供了高治疗效率和低药物副作用。这些发现极具意义，并将激励我们开发用于癌症治疗的高效MRI引导协同化学/光热疗法。
Zotero 插件