慢性丙型肝炎感染的皮肤表现。

Dermatologic Manifestations of Chronic Hepatitis C Infection.

机构信息

Betty and Guy Beatty Center for Integrated Research, Inova Health System, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA; Department of Medicine, Center for Liver Disease, Inova Fairfax Hospital, Claude Moore Health Education and Research Building, 3rd Floor, 3300 Gallows Road, Falls Church, VA 22042, USA.

出版信息

Clin Liver Dis. 2017 Aug;21(3):555-564. doi: 10.1016/j.cld.2017.03.010. Epub 2017 Apr 25.

DOI:10.1016/j.cld.2017.03.010

PMID:28689593

Abstract

Chronic hepatitis C virus (HCV) infection is associated with various extrahepatic manifestations, including dermatologic involvement mostly caused by immune complexes. Mixed cryoglobulinemia has a strong relationship with HCV with 95% of these patients being infected with HCV. Lichen planus is a disease of the squamous epithelium and may affect any part of the skin, with 4% to 24% of patients with lichen planus reported to have chronic HCV infection. Porphyria cutanea tarda is the most common form of porphyria, and it is thought that HCV interferes with iron stores, which can promote porphyria cutanea tarda. Finally, necrolytic acral erythema is a rare, psoriasis-like disease closely associated with HCV.

摘要

慢性丙型肝炎病毒（HCV）感染与多种肝外表现相关，包括主要由免疫复合物引起的皮肤受累。混合性冷球蛋白血症与 HCV 密切相关，其中 95%的患者感染了 HCV。扁平苔藓是一种鳞状上皮疾病，可能影响皮肤的任何部位，据报道，4%至 24%的扁平苔藓患者患有慢性 HCV 感染。迟发性皮肤卟啉病是最常见的卟啉病，据认为 HCV 干扰铁储存，从而促进迟发性皮肤卟啉病。最后，坏疽性肢端红斑是一种罕见的、类似银屑病的疾病，与 HCV 密切相关。