Yuan Shuwen, Lei Hui, Yao Shuqiao, Zhang Xiaocui
Department of Radiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.
College of Education, Hunan Agriculture University, Changsha 410128, China.
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2017 Jun 28;42(6):667-672. doi: 10.11817/j.issn.1672-7347.2017.06.012.
To explore the grey matter concentration in individuals with cognitive vulnerability to depression. Methods: Thirty individuals with cognitive vulnerability to depression and thirty age- and gender-matched healthy controls were enrolled in this study, and they were subjected to magnetic resonance imaging (MRI) examination. The grey matter concentration differences were compared between the two groups by using voxel-based morphometry (VBM) following MRI. Results: Individuals with cognitive vulnerability to depression showed significantly lower grey matter density in bilateral insular, left cerebellum, right supplementary motor area, and left precentral gyrus than those in the healthy controls, while the healthy controls showed significantly lower grey density in the right inferior frontal gyrus, right middle frontal gyrus, and left cuneus than those in the individuals with cognitive vulnerability to depression. Conclusion: Structural brain abnormalities in individuals with cognitive vulnerability to depression might be the neural basis for cognitive vulnerability to depression.
探索具有抑郁症认知易感性个体的灰质浓度。
本研究纳入了30名具有抑郁症认知易感性的个体和30名年龄及性别匹配的健康对照者，并对他们进行了磁共振成像（MRI）检查。MRI后采用基于体素的形态学测量（VBM）比较两组之间的灰质浓度差异。
具有抑郁症认知易感性的个体在双侧岛叶、左侧小脑、右侧辅助运动区和左侧中央前回的灰质密度显著低于健康对照者，而健康对照者在右侧额下回、右侧额中回和左侧楔叶的灰质密度显著低于具有抑郁症认知易感性的个体。
具有抑郁症认知易感性个体的脑结构异常可能是抑郁症认知易感性的神经基础。
