Wang Chunyan, Tang Xudong, Zhang Li
Institute of Digestive Diseases, China-Canada Center of Research for Digestive Diseases (ccCRDD), Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing 100091, China.
Evid Based Complement Alternat Med. 2017;2017:7016468. doi: 10.1155/2017/7016468. Epub 2017 Jun 12.
Ulcerative colitis (UC) is the most common inflammatory bowel disease worldwide. Current therapies in UC cause limitations, and herb medicine provides an important choice for UC treatment. Huangqin-Tang (HQT) is a well-known classical traditional Chinese herbal formula and has been used in China for thousands of years. A large number of pharmacological studies demonstrated HQT and its ingredients to be effective in treating UC. Though the therapeutic effect has been evaluated, comprehensive up-to-date reviews in this field are not yet available. Here we aim to review our current understanding of HQT and its ingredients in treating UC and how the agents modulate the main pathogenesis of the disease, including the intestinal environment, immune imbalance, inflammatory pathways, and oxidative stress. The summary on this issue may provide better understanding of HQT and its ingredients in treating UC and possibly help in promoting its clinical application.
溃疡性结肠炎（UC）是全球最常见的炎症性肠病。目前UC的治疗方法存在局限性，草药为UC治疗提供了重要选择。黄芩汤（HQT）是著名的经典中药方剂，在中国已使用数千年。大量药理研究表明，HQT及其成分对治疗UC有效。尽管其治疗效果已得到评估，但该领域尚未有全面的最新综述。在此，我们旨在综述目前对HQT及其成分治疗UC的认识，以及这些药物如何调节该疾病的主要发病机制，包括肠道环境、免疫失衡、炎症途径和氧化应激。关于这个问题的总结可能有助于更好地理解HQT及其成分在治疗UC中的作用，并可能有助于促进其临床应用。
