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颈椎硬膜外脓肿:与文献的单中心分析比较

Cervical spine epidural abscess: a single center analytical comparison to the literature.

作者信息

Shweikeh Faris, Hussain Mohammed, Sangtani Ajleeta, Issa Husam, Bashir Asif, Johnson J Patrick, Markarian Georges Z

机构信息

Summa Health System, College of Medicine, Northeast Ohio Medical University, Rootstown, OH, USA.

Department of Neurosurgery, Cedars-Sinai Medical Center, Maxine Dunitz Neurosurgical Institute, Advanced Health Sciences Pavilion, Los Angeles, CA, USA.

出版信息

Spinal Cord Ser Cases. 2017 Jul 6;3:17036. doi: 10.1038/scsandc.2017.36. eCollection 2017.

Abstract

STUDY DESIGN

Retrospective review of patient charts.

OBJECTIVES

Cervical spine epidural abscess (CSEA) is uncommon. In this study, characteristics of CSEA patients are described through an institutional analysis and literature review.

SETTING

University-affiliated city hospital.

METHODS

The electronic medical record was searched from 01/2001 to 01/2012. Data on presentation, comorbidities, diagnostic modalities, pathogens, treatments, and neurological recovery were collected.

RESULTS

Sixteen patients were identified with a mean age of 57.9 years (33-83). Nine were females. Common symptoms were neck/back pain (62.5%), neurological deficits (62.5%), and fever (31.3%). Comorbidities included cardiovascular disease (56.3%), renal disease (37.5%), and diabetes mellitus (37.5%). Lower levels were more likely afflicted (C5-C7). Microorganisms were commonly Staphylococcus and Streptococcus (68.8%). Eight (50.0%) received surgery (anterior [87.5%] and posterior [12.5%] cervical fusion and corpectomy [37.5%]) plus antibiotics and 8 (50.0%) were treated with antibiotics only. Patients with less comorbidities were more likely to receive surgery; more comorbidities were was associated with a poor prognosis. Eight patients (50%) made had full neurological recovery, 2 (12.5%) with had minimal recovery, 2 deaths died, and the remaining (25%) 1 was were sent to a skilled facility and 1or lost to follow-up.

CONCLUSIONS

Cervical SEA can be problematic. The vast majority do not present classically and treatment does vary. It occurs more frequently in the lower cervical levels. Though antibiotics alone may suffice, surgery is frequently employed and a multitude of techniques are at the utility of the spine surgeon. Cardiovascular comorbidities are associated with a poorer outcome. In order to improve prognosis, management considerations should include both patient factors and multidisciplinary efforts.

摘要

研究设计

对患者病历进行回顾性分析。

目的

颈椎硬膜外脓肿(CSEA)较为罕见。本研究通过机构分析和文献回顾描述CSEA患者的特征。

研究地点

大学附属医院。

方法

检索2001年1月至2012年1月的电子病历。收集有关临床表现、合并症、诊断方式、病原体、治疗方法及神经功能恢复的数据。

结果

共确定16例患者,平均年龄57.9岁(33 - 83岁)。其中9例为女性。常见症状包括颈/背痛(62.5%)、神经功能缺损(62.5%)和发热(31.3%)。合并症包括心血管疾病(56.3%)、肾脏疾病(37.5%)和糖尿病(37.5%)。较低节段(C5 - C7)更易受累。常见微生物为葡萄球菌和链球菌(68.8%)。8例(50.0%)接受了手术(前路颈椎融合术[87.5%]和后路颈椎融合术[12.5%]以及椎体次全切除术[37.5%])加抗生素治疗,8例(50.0%)仅接受抗生素治疗。合并症较少的患者更有可能接受手术;合并症较多与预后不良相关。8例患者(50%)神经功能完全恢复,2例(12.5%)恢复甚微,2例死亡,其余(25%)1例被送至专业护理机构,1例失访。

结论

颈椎SEA可能存在问题。绝大多数患者临床表现不典型,治疗方法各异。其在下颈椎节段更为常见。虽然单独使用抗生素可能足够,但手术也经常被采用,脊柱外科医生有多种技术可供选择。心血管合并症与较差的预后相关。为改善预后,管理方面应综合考虑患者因素和多学科协作。

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