Olowe Olugbenga A, Makanjuola Olufunmilola B, Adekanmi Adeniyi S, Adefioye Olusola J, Olowe Rita A
Department of Medical Microbiology and Parasitology, College of Health Sciences, Ladoke Akintola University of Technology Ogbomoso, P.M.B. 4400, Osogbo, Nigeria.
Department of Medical Microbiology and Parasitology, College of Medicine, University of Ibadan, Nigeria.
Eur J Microbiol Immunol (Bp). 2017 Apr 26;7(2):127-132. doi: 10.1556/1886.2017.00003. eCollection 2017 Jun.
Tuberculosis (TB) is the second leading cause of death from infectious disease globally with its impact more dramatic in resource limited settings. Individuals with human immunodeficiency virus (HIV) infection who also develop tuberculosis represent a significant challenge to TB control. This study was carried out to determine the prevalence of TB-HIV coinfection and pattern of infection among TB patients. We also compared treatment outcome among coinfected patients with those not coinfected. A six-year retrospective review of records of patients managed at the Tuberculosis Treatment Center of the LAUTECH Teaching Hospital, South-Western Nigeria from January 2009 to December 2014 was carried out. One hundred and five (26.3%) of the 399 TB patients seen in the study period were coinfected with HIV. About 10% of the subjects had extrapulmonary tuberculosis. Treatment failure was significantly worse among patients who had both HIV and TB compared with those who had TB only (49.5% vs. 32%, = 0.001). Death rate was also higher in the coinfected individuals implying a poorer clinical outcome. High prevalence of TB-HIV coinfection and poor treatment outcome in this group of individuals, though predictable, calls for a more concerted effort in the management of TB-HIV coinfection.
结核病（TB）是全球第二大致死性传染病，在资源有限的地区其影响更为显著。同时感染人类免疫缺陷病毒（HIV）和结核病的个体对结核病控制构成了重大挑战。开展本研究以确定结核病患者中结核-艾滋病病毒合并感染的患病率及感染模式。我们还比较了合并感染患者与未合并感染患者的治疗结果。对2009年1月至2014年12月在尼日利亚西南部LAUTECH教学医院结核病治疗中心接受治疗的患者记录进行了为期六年的回顾性研究。在研究期间就诊的399例结核病患者中，105例（26.3%）合并感染了HIV。约10%的受试者患有肺外结核。与仅患结核病的患者相比，同时感染HIV和结核病的患者治疗失败情况明显更糟（49.5%对32%，P = 0.001）。合并感染个体的死亡率也更高，这意味着临床结果更差。尽管在这组个体中结核-艾滋病病毒合并感染的高患病率和较差的治疗结果是可预测的，但仍需要在结核-艾滋病病毒合并感染的管理方面做出更协调一致的努力。
