Aşkar Tünay K, Büyükleblebici Olga, Hismioğulları Adnan Adil, Hünkerler Zeynep
Department of Biochemistry, Health Sciences Faculty, Çankırı Karotekin University, Turkey.
Department of Biochemistry, Veterinary Faculty, Aksaray University, Turkey.
Adv Clin Exp Med. 2017 Jul;26(4):621-625. doi: 10.17219/acem/62829.
Anemia is a disease that is long and often repetitive and can result in a great burden to the national economy. The most frequent nutritional deficiency anemias in children are related with iron and vitamin B12 deficiencies.
The aim of this study was to determine the oxidative stress, hepcidin, and nesfatin-I levels in childhood iron and vitamin B12 deficiency anemias.
The study had 3 groups of 15 children, iron anemia deficiency group, vitamin B12 deficiency group and a control group.
The TBARS and nesfatin-I levels were significantly higher in the iron and vitamin B12 deficiency groups and the total antioxidant levels were significantly lower when compared to the control group. In contrast, the plasma hepcidin levels were significantly lower in the iron deficiency group (p < 0.01) when compared to the control group; however, no significant differences were observed in the vitamin B12 deficiency group. Plasma homocysteine levels were significantly higher in the vitamin B12 deficiency group when compared to the control group (p < 0.001), but no differences were determined between the iron deficiency and control groups.
Our results showed that there are high levels of oxidative stress in childhood iron and vitamin B12 deficiency anemias, and we propose that plasma hepcidin and homocycteine levels may be useful in the differential diagnosis of childhood nutritional deficiency anemias. Nesfatin-1 hormone levels were identified for the first time in childhood iron deficiency and vitamin B12 deficiency anemias within this study and this hormone may also be useful in the differential diagnosis of anemias.
贫血是一种病程长且常反复的疾病，会给国民经济带来巨大负担。儿童中最常见的营养性缺铁性贫血与铁和维生素B12缺乏有关。
本研究旨在测定儿童铁和维生素B12缺乏性贫血中的氧化应激、铁调素和奈斯芬汀-1水平。
该研究有3组，每组15名儿童，分别为缺铁性贫血组、维生素B12缺乏组和对照组。
与对照组相比，缺铁和维生素B12缺乏组的硫代巴比妥酸反应物（TBARS）和奈斯芬汀-1水平显著升高，总抗氧化水平显著降低。相比之下，缺铁组的血浆铁调素水平与对照组相比显著降低（p<0.01）；然而，维生素B12缺乏组未观察到显著差异。维生素B12缺乏组的血浆同型半胱氨酸水平与对照组相比显著升高（p<0.001），但缺铁组与对照组之间未发现差异。
我们的结果表明，儿童铁和维生素B12缺乏性贫血中存在高水平的氧化应激，我们提出血浆铁调素和同型半胱氨酸水平可能有助于儿童营养性缺铁性贫血的鉴别诊断。在本研究中首次在儿童缺铁和维生素B12缺乏性贫血中鉴定出奈斯芬汀-1激素水平，该激素也可能有助于贫血的鉴别诊断。
