Askar Sinasi, Deveboynu Seyma Nur, Er Hilal, Askar Tunay Kontas, Hismiogullari Adnan Adil
Sinasi Askar Assistant Professor, Department of Nutrition and Dietetics, Cankiri Karatekin University, Cankiri, Turkey.
Seyma Nur Deveboynu Res Assistant, Department of Nutrition and Dietetics, Cankiri Karatekin University, Cankiri, Turkey.
Pak J Med Sci. 2019 Mar-Apr;35(2):298-301. doi: 10.12669/pjms.35.2.520.
Iron Deficiency Anemia (IDA) is common nutritional deficiency particularly in women and also common during the older age. Aging increases plasma levels of inflammatory mediators such as pro-inflammatory cytokines and acute phase proteins. However, there is little information about changes in antimicrobial proteins in elderly women with IDA. In this study, we aimed to determine the changes in pro-inflammatory cytokines and newly discovered antimicrobial proteins like hepcidin, chemerin and defensin in elderly women with IDA.
Blood samples taken from healthy 20 women (55±7 years old) and 20 women with iron deficiency anemia (58±6) were used as material of the study that came to the Cankiri State Hospital in 2016 and 2017 years.
In the study, plasma C-Reactive Protein (CRP) (P <0.01), tumour necrosis factor-α (TNF-α) (P <0.05) and interleukin-6 (IL-6) levels (P <0.05) were significantly increased in group with IDA when compared with healthy group. Also plasma hepcidin (P <0.001), chemerin (P <0.05) and defensin levels (P <0.05) were determined significantly higher than the healthy group.
We found that inflammatory changes occur in elderly women with IDA. Besides pro-inflammatory cytokine levels (CRP, IL-6, TNF-α), antimicrobial protein levels (hepcidin, chemerin, defensin) were found higher in elderly women with IDA because of inflammatory changes.
缺铁性贫血（IDA）是一种常见的营养缺乏症，尤其在女性中常见，在老年人群中也较为普遍。衰老会使促炎细胞因子和急性期蛋白等炎症介质的血浆水平升高。然而，关于老年缺铁性贫血女性抗菌蛋白变化的信息较少。在本研究中，我们旨在确定老年缺铁性贫血女性促炎细胞因子以及新发现的抗菌蛋白（如铁调素、趋化素和防御素）的变化。
从2016年和2017年到坎基里州立医院就诊的20名健康女性（55±7岁）和20名缺铁性贫血女性（58±6岁）采集血液样本作为研究材料。
在该研究中，与健康组相比，缺铁性贫血组血浆C反应蛋白（CRP）（P<0.01）、肿瘤坏死因子-α（TNF-α）（P<0.05）和白细胞介素-6（IL-6）水平（P<0.05）显著升高。此外，还测定了血浆铁调素（P<0.001）、趋化素（P<0.05）和防御素水平（P<0.05）显著高于健康组。
我们发现老年缺铁性贫血女性存在炎症变化。除了促炎细胞因子水平（CRP、IL-6、TNF-α）外，由于炎症变化，老年缺铁性贫血女性的抗菌蛋白水平（铁调素、趋化素、防御素）也较高。
