Bura Maciej, Bukowska Alicja, Bura Aleksandra, Michalak Michał, Mozer-Lisewska Iwona
Department of Infectious Diseases, Hepatology and Acquired Immunodeficiences, Poznan University of Medical Sciences, Poland.
Regional Blood Center, Poznań, Poland.
Adv Clin Exp Med. 2017 Jul;26(4):577-579. doi: 10.17219/acem/62353.
Hepatitis E virus (HEV) infection is an emerging problem in industrialized countries, including Europe. Little data exists on HEV seroprevalence in Poland.
The aim of this study was to assess the prevalence of anti-HEV IgG antibodies in Polish patients infected with the human immunodeficiency virus (HIV) and blood donors.
Two hundred and ten individuals (n = 105 of HIV-infected patients and n = 105 of ageand sex-matched blood donors from the same area; 178 men and 32 women), aged 18-50 (median age: 38 years), were tested for the presence of anti-HEV IgG antibodies with the EUROIMMUN Anti-Hepatitis E Virus (HEV) ELISA (IgG) tests (Lübeck, Germany). Additionally, some simple clinical and laboratory data was collected.
The overall anti-HEV IgG prevalence was 2.4% (5/210). One HIV-positive patient (0.95%) and 4 blood donors (3.8%) were seropositive (p = 0.1745). All the HEV-exposed individuals were men with a history of travel abroad and no icteric disease in the past.
Exposure to HEV infection among Polish HIV patients and blood donors seems to be uncommon. Data on this issue is scarce and conflicting for HIV-infected individuals. Further investigations applying different serological tests and concomitant HEV RNA testing are needed to reliably assess the risk and practical impact of HEV infection in Poland.
戊型肝炎病毒（HEV）感染在包括欧洲在内的工业化国家正成为一个新出现的问题。波兰关于HEV血清流行率的数据很少。
本研究的目的是评估波兰感染人类免疫缺陷病毒（HIV）的患者和献血者中抗HEV IgG抗体的流行率。
对210名年龄在18至50岁（中位年龄：38岁）的个体（105名HIV感染患者和来自同一地区的105名年龄和性别匹配的献血者；178名男性和32名女性）进行检测，采用德国吕贝克市EUROIMMUN抗戊型肝炎病毒（HEV）ELISA（IgG）检测法检测抗HEV IgG抗体的存在情况。此外，还收集了一些简单的临床和实验室数据。
抗HEV IgG总体流行率为2.4%（5/210）。1名HIV阳性患者（0.95%）和4名献血者（3.8%）血清学呈阳性（p = 0.1745）。所有接触过HEV的个体均为有出国旅行史且过去无黄疸疾病的男性。
波兰HIV患者和献血者中接触HEV感染的情况似乎不常见。关于这一问题的数据对于HIV感染个体来说稀少且相互矛盾。需要采用不同血清学检测方法并同时进行HEV RNA检测的进一步研究，以可靠评估波兰HEV感染的风险和实际影响。
