松塔酮和松塔烯酸，两种来自可食用蘑菇松露的具有不寻常骨架的（降）甾体。
Matsutakone and Matsutoic Acid, Two (Nor)steroids with Unusual Skeletons from the Edible Mushroom Tricholoma matsutake.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201, P. R. China.
University of Chinese Academy of Sciences , Beijing 100049, P. R. China.
出版信息
J Org Chem. 2017 Aug 4;82(15):7974-7979. doi: 10.1021/acs.joc.7b01230. Epub 2017 Jul 19.
Matsutakone (1), a novel sterol with an unprecedented polycyclic ring system, together with a new norsteroid matsutoic acid (2) were isolated from the fruiting bodies of Tricholoma matsutake. Their structures and absolute configurations were assigned by extensive spectroscopic analyses and computational methods. Bioassay results showed that compounds 1 and 2 exhibited inhibitory activities against acetylcholinesterase (IC 20.9 μM for 1).
从松口蘑的子实体中分离得到了一种新型甾体化合物 Matsutakone（1），其具有前所未有的多环体系，以及一种新的降胆甾烷酸 Matsutoic acid（2）。通过广泛的光谱分析和计算方法确定了它们的结构和绝对构型。生物测定结果表明，化合物 1 和 2 对乙酰胆碱酯酶具有抑制活性（化合物 1 的 IC 20.9 μM）。
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