Adetona Anna M, Adetona Olorunfemi, Gogal Robert M, Diaz-Sanchez David, Rathbun Stephen L, Naeher Luke P
Department of Environmental Health Science (Dr A Adetona, Dr O Adetona, Dr Naeher); Division of Environmental Health Sciences, College of Public Health, The Ohio State University, Columbus, Ohio (Dr O Adetona); Department of Veterinary Biosciences and Diagnostic Imaging, College of Veterinary Medicine (Dr Gogal); The United States Environmental Protection Agency, Environmental Public Health Division, Clinical Research Branch, North Carolina (Dr Diaz-Sanchez); and Department of Epidemiology and Biostatistics (Dr Rathbun), College of Public Health, The University of Georgia, Athens, Georgia.
J Occup Environ Med. 2017 Jul;59(7):679-690. doi: 10.1097/JOM.0000000000001053.
A repeated measures study was used to assess the effect of work tasks on select proinflammatory biomarkers in firefighters working at prescribed burns.
Ten firefighters and two volunteers were monitored for particulate matter and carbon monoxide on workdays, January to July 2015. Before and after workshift dried blood spots were analyzed for inflammatory mediators using the Meso Scale Discovery assay, while blood smears were used to assess leukocyte parameters.
Firefighters lighting with drip-torches had higher cross-work-shift increases in interleukin-8, C-reactive protein, and serum amyloid A compared with holding, a task involving management of fire boundaries. A positive association between interleukin-8 and segmented-neutrophil was observed.
Results from this study suggest that intermittent occupational diesel exposures contribute to cross-work-shift changes in host systemic innate inflammation as indicated by elevated interleukin-8 levels and peripheral blood segmented-neutrophils.
采用重复测量研究来评估工作任务对参与规定性焚烧工作的消防员体内特定促炎生物标志物的影响。
在2015年1月至7月的工作日期间，对10名消防员和2名志愿者进行了颗粒物和一氧化碳监测。在轮班前和轮班后，使用微尺度发现分析方法对干血斑中的炎症介质进行分析，同时利用血涂片评估白细胞参数。
与负责控制火势边界的“坚守”任务相比，使用滴液喷灯点火的消防员在轮班期间白细胞介素-8、C反应蛋白和血清淀粉样蛋白A的增加幅度更大。观察到白细胞介素-8与分叶核中性粒细胞之间存在正相关。
本研究结果表明，间歇性职业性柴油暴露会导致宿主全身先天性炎症在轮班期间发生变化，表现为白细胞介素-8水平升高和外周血分叶核中性粒细胞增多。
