Gaitor Jamie C, Paul Lauren M, Reardon Melissa M, Hmissa Taha, Minkowicz Samuel, Regner Matthew, Sheng Yinghong, Michael Scott F, Isern Sharon, Mirjafari Arsalan
Department of Chemistry and Physics, Florida Gulf Coast University, Fort Myers, Florida 33965, USA.
Chem Commun (Camb). 2017 Jul 20;53(59):8328-8331. doi: 10.1039/c7cc03235h.
This study introduces a novel class of imidazolium- and ammonium-based ionic liquids possessing two C and C tails and thioether linkers designed for lipoplex-mediated DNA delivery. Imidazolium-based ionic liquids displayed efficient gene delivery properties with low toxicity. Thiol-yne click chemistry was employed for the facile and robust synthesis of these thioether-based cationic lipioids with enhanced lipophilicity and low fluidity.
本研究介绍了一类新型的基于咪唑鎓和铵的离子液体，其具有两条碳链和硫醚连接基，专为脂质体介导的DNA递送而设计。基于咪唑鎓的离子液体表现出高效的基因递送特性且毒性较低。硫醇-炔点击化学被用于简便且稳健地合成这些具有增强亲脂性和低流动性的基于硫醚的阳离子脂质。
