a College of Pharmacy, Henan University , Kaifeng , P. R. China.
b Key Laboratory of Marine Biogenetic Resources, Third Institute of Oceanography State Oceanic Administration , Xiamen , P. R. China.
Nat Prod Res. 2019 Oct;33(20):2988-2994. doi: 10.1080/14786419.2018.1514402. Epub 2018 Oct 1.
A new indole diterpene, named penicindopene A (), together with seven known compounds (-), was isolated from the deep-sea fungus sp. YPCMAC1. The structure of penicindopene A was elucidated by extensive spectroscopic analyses (1 D and 2 D NMR, and HRESIMS data), in addition to the ECD calculations for the assignments of its absolute configuration. Penicindopene A represented the first example of indole diterpenes possessing a 3-hydroxyl-2-indolone moiety, and it exhibited moderate cytotoxicities against A549 and HeLa cell lines with IC values of 15.2 and 20.5 M, respectively.
从深海真菌 sp. YPCMAC1 中分离得到一种新的吲哚二萜类化合物，命名为 penicindopene A ()，此外还分离得到了 7 种已知化合物 (-)。通过广泛的光谱分析（1D 和 2D NMR，以及 HRESIMS 数据）以及 ECD 计算确定了 penicindopene A 的结构，用于确定其绝对构型。Penicindopene A 代表了具有 3-羟基-2-吲哚酮部分的吲哚二萜类化合物的首例，对 A549 和 HeLa 细胞系表现出中等的细胞毒性，IC 值分别为 15.2 和 20.5μM。
