青霉烯 J，一种新型青霉烯生物碱，来源于深海来源真菌 Penicillium granulatum MCCC 3A00475。

Roquefortine J, a novel roquefortine alkaloid, from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475.

机构信息

State Key Laboratory Breeding Base of Marine Genetic Resources, Key Laboratory of Marine Genetic Resources, Fujian Key Laboratory of Marine Genetic Resources, Third Institute of Oceanography, State Oceanic Administration, 184 Daxue Road, Xiamen, 361005, China.

Department of Oncology, Luxembourg Institute of Health, 84 Val Fleuri, L-1526, Luxembourg, Luxembourg.

出版信息

J Antibiot (Tokyo). 2018 Jul;71(7):658-661. doi: 10.1038/s41429-018-0046-y. Epub 2018 Apr 4.

DOI:10.1038/s41429-018-0046-y

PMID:29618769

Abstract

Chemical investigation on the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475 led to the isolation of a previously undescribed (roquefortine J, 1) and four known (2-5) roquefortine alkaloids, along with six ergosterol analogues (6-11). The planar structure of 1 was established mainly on the basis of extensive analysis of its 1D, 2D NMR, and HRESIMS spectra. The absolute configuration of 1 was determined by comparison of the calculated and experimental electronic circular dichroism spectra. Compounds 5, 6, and 7 exhibited potent anti-proliferative effects against HepG2 tumor cells with IC values of 7.0, 8.6, and 8.2 μM, respectively.

摘要

从深海真菌青霉 MCCC 3A00475 中分离得到了一种先前未被描述的（罗奎福汀 J，1）和四种已知的（2-5）罗奎福汀生物碱，以及六种麦角甾醇类似物（6-11）。1 的平面结构主要是基于对其 1D、2D NMR 和 HRESIMS 光谱的广泛分析来确定的。通过比较计算和实验电子圆二色谱光谱，确定了 1 的绝对构型。化合物 5、6 和 7 对 HepG2 肿瘤细胞表现出很强的抗增殖活性，IC 值分别为 7.0、8.6 和 8.2 μM。