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深海真菌 MCCC 3A00475 来源的甾体通过视黄醇 X 受体 (RXRα) 通路诱导细胞凋亡。

Steroids from the Deep-Sea-Derived Fungus MCCC 3A00475 Induced Apoptosis via Retinoid X Receptor ()-α Pathway.

机构信息

School of Pharmaceutical Sciences, Xiamen University, South Xiangan Road, Xiamen 361005, China.

Key Laboratory of Marine Biogenetic Resources, South China Sea Bio-Resource Exploitation and Utilization Collaborative Innovation Center, Third Institute of Oceanography, Ministry of Natural Resources, 184 Daxue Road, Xiamen 361005, China.

出版信息

Mar Drugs. 2019 Mar 19;17(3):178. doi: 10.3390/md17030178.

DOI:10.3390/md17030178
PMID:30893778
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6472029/
Abstract

Five new ergostanes, penicisteroids D-H (-), were isolated from the liquid culture of the deep-sea-derived fungus MCCC 3A00475, along with 27 known compounds. The structures of the new steroids were established mainly on the basis of extensive analysis of 1D and 2D NMR as well as HRESIMS data. Moreover, the absolute configurations of were confirmed unambiguously by the single-crystal X-ray crystallography. Compounds and ⁻ showed moderate antiproliferative effects selectively against 12 different cancer cell lines with IC values of around 5 μM. Compounds and , potent binders with Kd values of 13.8 and 12.9 μM, respectively, could induce apoptosis by a Retinoid X Receptor ()--dependent mechanism by regulating RXRα transcriptional expression and promoting the poly-ADP-ribose polymerase (PARP) cleavage. Moreover, they could inhibit proliferation by cell cycle arrest at the G0/G1 phase.

摘要

从深海来源的真菌 MCCC 3A00475 的液体培养物中分离得到了 5 个新的麦角甾烷，penicisteroids D-H (-)，以及 27 个已知化合物。新甾体的结构主要是基于 1D 和 2D NMR 以及 HRESIMS 数据的广泛分析确定的。此外，通过单晶 X 射线晶体学明确确定了的绝对构型。化合物和 ⁻ 对 12 种不同的癌细胞系表现出中等的选择性抗增殖作用，IC 值约为 5 μM。化合物和 ⁻ 是有效的结合物，其 Kd 值分别为 13.8 和 12.9 μM，通过调节 RXRα 转录表达和促进聚 ADP-核糖聚合酶 (PARP) 切割，以视黄酸 X 受体 () 依赖性机制诱导细胞凋亡。此外，它们可以通过将细胞周期阻滞在 G0/G1 期来抑制增殖。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/b25b3c2e5ca5/marinedrugs-17-00178-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/4d6696f2d308/marinedrugs-17-00178-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/7204797ad01d/marinedrugs-17-00178-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/b2fcf41aa68a/marinedrugs-17-00178-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/cf007d12c19d/marinedrugs-17-00178-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/4979cb8555af/marinedrugs-17-00178-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/64dea16f72be/marinedrugs-17-00178-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/38cf1dbf01e0/marinedrugs-17-00178-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/27394271244d/marinedrugs-17-00178-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/11a714ed51a9/marinedrugs-17-00178-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/b25b3c2e5ca5/marinedrugs-17-00178-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/4d6696f2d308/marinedrugs-17-00178-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/7204797ad01d/marinedrugs-17-00178-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/b2fcf41aa68a/marinedrugs-17-00178-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/cf007d12c19d/marinedrugs-17-00178-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/4979cb8555af/marinedrugs-17-00178-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/64dea16f72be/marinedrugs-17-00178-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/38cf1dbf01e0/marinedrugs-17-00178-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/27394271244d/marinedrugs-17-00178-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/11a714ed51a9/marinedrugs-17-00178-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d368/6472029/b25b3c2e5ca5/marinedrugs-17-00178-g010.jpg

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Phytochemistry. 2019 Feb;158:67-76. doi: 10.1016/j.phytochem.2018.10.036. Epub 2018 Nov 24.
2
Penicisteroid C: New polyoxygenated steroid produced by co-culturing of Streptomyces piomogenus with Aspergillus niger.青霉甾体C：由产黄链霉菌与黑曲霉共培养产生的新型多氧化甾体。
Steroids. 2018 Oct;138:21-25. doi: 10.1016/j.steroids.2018.06.005. Epub 2018 Jun 15.
3
Roquefortine J, a novel roquefortine alkaloid, from the deep-sea-derived fungus Penicillium granulatum MCCC 3A00475.
RSC Adv. 2024 Nov 14;14(49):36451-36460. doi: 10.1039/d4ra06840h. eCollection 2024 Nov 11.
4
Rapid Discovery of Substances with Anticancer Potential from Marine Fungi Based on a One Strain-Many Compounds Strategy and UPLC-QTOF-MS.基于单菌多种化合物策略和 UPLC-QTOF-MS 的海洋真菌中抗癌潜力物质的快速发现
Mar Drugs. 2023 Dec 18;21(12):646. doi: 10.3390/md21120646.
5
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Nat Commun. 2023 Sep 2;14(1):5351. doi: 10.1038/s41467-023-41114-y.
6
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J Antibiot (Tokyo). 2023 Sep;76(9):563-566. doi: 10.1038/s41429-023-00634-x. Epub 2023 May 31.
7
Bioactive and unusual steroids from Penicillium fungi.从青霉菌中提取的具有生物活性和不寻常的甾体。
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8
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4
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5
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7
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J Nat Prod. 2017 Jul 28;80(7):2174-2177. doi: 10.1021/acs.jnatprod.7b00475. Epub 2017 Jul 10.
8
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Curr Top Med Chem. 2017;17(6):663-675. doi: 10.2174/1568026616666160617092241.
9
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10
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Bioorg Med Chem. 2014 May 1;22(9):2671-7. doi: 10.1016/j.bmc.2014.03.024. Epub 2014 Mar 24.