Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota, USA.
Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA.
Alzheimers Dement. 2021 May;17(5):801-812. doi: 10.1002/alz.12239. Epub 2021 Mar 4.
We determined whether cerebrospinal fluid (CSF) neurofilament light (NfL), neurogranin (Ng), and total-tau (t-tau) differentially mapped to magnetic resonance imaging (MRI) measures of cortical thickness, microstructural integrity (corpus callosum and cingulum fractional anisotropy [FA]), and white matter hyperintensities (WMH).
Analyses included 536 non-demented Mayo Clinic Study of Aging participants with CSF NfL, Ng, t-tau, amyloid beta (Aβ)42 and longitudinal MRI scans. Linear mixed models assessed longitudinal associations between CSF markers and MRI changes.
Higher CSF NfL was associated with decreasing microstructural integrity and WMH. Higher t-tau was associated with decreasing temporal lobe and Alzheimer's disease (AD) meta region of interest (ROI) cortical thickness. There was no association between Ng and any MRI measure. CSF Aβ42 interacted with Ng for declines in temporal lobe and AD meta ROI cortical thickness and cingulum FA.
CSF NfL predicts changes in white matter integrity, t-tau reflects non-specific changes in cortical thickness, and Ng reflects AD-specific synaptic and neuronal degeneration.
我们确定了脑脊液（CSF）神经丝轻链（NfL）、神经颗粒素（Ng）和总 tau（t-tau）是否与磁共振成像（MRI）测量的皮质厚度、微观结构完整性（胼胝体和扣带回分数各向异性 [FA]）和脑白质高信号（WMH）有差异。
分析包括 536 名无痴呆的梅奥诊所老龄化研究参与者的 CSF NfL、Ng、t-tau、淀粉样蛋白β（Aβ）42 和纵向 MRI 扫描。线性混合模型评估了 CSF 标志物与 MRI 变化之间的纵向关联。
较高的 CSF NfL 与微观结构完整性和 WMH 的减少有关。较高的 t-tau 与颞叶和阿尔茨海默病（AD）的 ROI 皮质厚度减少有关。Ng 与任何 MRI 测量都没有关联。CSF Aβ42 与 Ng 相互作用，导致颞叶和 AD 元 ROI 皮质厚度以及扣带回 FA 的下降。
CSF NfL 预测白质完整性的变化，t-tau 反映皮质厚度的非特异性变化，而 Ng 反映 AD 特异性的突触和神经元退化。
