血浆同型半胱氨酸水平与校正QT间期相关。
Plasma homocysteine levels associated with a corrected QT interval.
作者信息
Li Zhao, Guo Xiaofan, Sun Guozhe, Zheng Liqiang, Sun Yingxian, Liu Yamin, Abraham Maria Roselle
机构信息
Department of Cardiology, the First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang, 110001, People's Republic of China.
Department of Clinical Epidemiology, Library, Shengjing Hospital of China Medical University, Shenyang, Liaoning, People's Republic of China.
出版信息
BMC Cardiovasc Disord. 2017 Jul 11;17(1):182. doi: 10.1186/s12872-017-0617-z.
BACKGROUND
Little is known about the relationship between homocysteine (Hcy) levels and the QT interval. We examined the association of different Hcy levels with corrected QT (QTc) intervals in a general population.
METHODS
Plasma levels of Hcy were assessed in a population-based study of 7002 participants 35 years of age and older from 2012 to 2013. Twelve-lead ECGs were performed on all participants and analyzed automatically.
RESULTS
The distribution of Hcy levels was determined for an entire population after the data were grouped into quartiles (Q1: <=11.1umol/L; Q2: 11.1-13.8umol/L; Q3: 13.8-18.2 umol/L; Q4 > 18.2 umol/L). The mean value of the QTc interval in each quartile was 433.2 ± 23.8 ms, 430.0 ± 24.6 ms, 429.2 ± 24.5 ms and 430.6 ± 25.7 ms. Multiple logistic regression analyses showed that, compared with the second quartile, and after fully adjusting for potential confounding factors, the odds for QTc > 440 ms in the first and fourth quartile increased (P < 0.05), (OR: 1.23, 95% CI: 1.05-1.43 for Q1; OR: 1.40, 95% CI: 1.19-1.65 for Q4).
CONCLUSIONS
QTc interval was associated with the Hcy level in this general population.
背景
关于同型半胱氨酸（Hcy）水平与QT间期之间的关系，目前所知甚少。我们在普通人群中研究了不同Hcy水平与校正QT（QTc）间期之间的关联。
方法
在一项基于人群的研究中，对2012年至2013年7002名35岁及以上参与者的血浆Hcy水平进行了评估。对所有参与者进行了12导联心电图检查并自动分析。
结果
将数据分为四分位数后（Q1：<=11.1umol/L；Q2：11.1 - 13.8umol/L；Q3：13.8 - 18.2umol/L；Q4 > 18.2umol/L），确定了整个人群中Hcy水平的分布。每个四分位数中QTc间期的平均值分别为433.2±23.8ms、430.0±24.6ms、429.2±24.5ms和430.6±25.7ms。多因素逻辑回归分析显示，与第二四分位数相比，在对潜在混杂因素进行充分校正后，第一和第四四分位数中QTc>440ms的几率增加（P<0.05），（Q1的OR：1.23，95%CI：1.05 - 1.43；Q4的OR：1.40，95%CI：1.19 - 1.65）。
结论
在该普通人群中，QTc间期与Hcy水平相关。
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