B细胞发育和淋巴瘤发生中的微小RNA
miRNAs in B Cell Development and Lymphomagenesis.
作者信息
Coffre Maryaline, Koralov Sergei B
机构信息
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.
Department of Pathology, New York University School of Medicine, New York, NY 10016, USA.
出版信息
Trends Mol Med. 2017 Aug;23(8):721-736. doi: 10.1016/j.molmed.2017.06.001. Epub 2017 Jul 7.
Abstract
B lymphocytes are essential for an efficient immune response against a variety of pathogens. A large fraction of hematologic malignancies is of B cell origin, suggesting that the development and activation of B cells need to be tightly regulated. In recent years, increasing evidence has emerged demonstrating that microRNAs (miRNAs) - a class of non-coding RNAs that control gene expression - are involved in the regulation of B cell development and function. We provide here an overview of the current knowledge on the role of miRNAs and their relevant targets in B cell development, B cell activation, and B cell malignant transformation.
摘要
B淋巴细胞对于针对多种病原体的有效免疫反应至关重要。很大一部分血液系统恶性肿瘤起源于B细胞，这表明B细胞的发育和激活需要受到严格调控。近年来，越来越多的证据表明，微小RNA（miRNA）——一类控制基因表达的非编码RNA——参与了B细胞发育和功能的调控。我们在此概述了目前关于miRNA及其相关靶点在B细胞发育、B细胞激活和B细胞恶性转化中的作用的知识。
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