生发中心 B 细胞的功能与淋巴瘤发生：涉及 MYC 和 microRNAs 的通路。

Germinal Centre B Cell Functions and Lymphomagenesis: Circuits Involving MYC and MicroRNAs.

机构信息

Programa de Pesquisa em Hemato-Oncologia Molecular, Coordenação de Pesquisa, Instituto Nacional de Câncer, Rio de Janeiro, CEP: 20230-130, Brazil.

出版信息

Cells. 2019 Oct 31;8(11):1365. doi: 10.3390/cells8111365.

DOI:10.3390/cells8111365

PMID:31683676

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6912346/

Abstract

BACKGROUND

The transcription factor MYC regulates several biological cellular processes, and its target gene network comprises approximately 15% of all human genes, including microRNAs (miRNAs), that also contribute to MYC regulatory activity. Although miRNAs are emerging as key regulators of immune functions, the specific roles of miRNAs in the regulation/dysregulation of germinal centre B-cells and B-cell lymphomas are still being uncovered. The regulatory network that integrates MYC, target genes and miRNAs is a field of intense study, highlighting potential pathways to be explored in the context of future clinical approaches.

METHODS

The scientific literature that is indexed in PUBMED was consulted for publications involving MYC and miRNAs with validated bioinformatics analyses or experimental protocols. Additionally, seminal studies on germinal centre B-cell functions and lymphomagenesis were reported.

CONCLUSIONS

This review summarizes the interactions between MYC and miRNAs through regulatory loops and circuits involving target genes in germinal centre B-cell lymphomas with MYC alterations. Moreover, we provide an overview of the understanding of the regulatory networks between MYC and miRNAs, highlighting the potential implication of this approach for the comprehension of germinal centre B-cell lymphoma pathogenesis. Therefore, circuits involving MYC, target genes and miRNAs provide novel insight into lymphomagenesis that could be useful for new improved therapeutic strategies.

摘要

背景

转录因子 MYC 调节多种生物学细胞过程，其靶基因网络约占所有人类基因的 15%，包括 microRNAs（miRNAs），它们也有助于 MYC 调节活性。尽管 miRNAs 作为免疫功能的关键调节剂而出现，但 miRNA 在生发中心 B 细胞和 B 细胞淋巴瘤的调节/失调中的具体作用仍在探索中。整合 MYC、靶基因和 miRNAs 的调控网络是一个研究热点，突出了在未来临床方法背景下探索的潜在途径。

方法

检索 PUBMED 索引的科学文献，寻找涉及 MYC 和 miRNA 的出版物，这些出版物具有经过验证的生物信息学分析或实验方案。此外，还报告了关于生发中心 B 细胞功能和淋巴瘤发生的开创性研究。

结论

本综述总结了 MYC 和 miRNA 之间通过涉及生发中心 B 细胞淋巴瘤中 MYC 改变的靶基因的调控环和电路的相互作用。此外，我们概述了 MYC 和 miRNA 之间的调控网络的理解，强调了这种方法对理解生发中心 B 细胞淋巴瘤发病机制的潜在意义。因此，涉及 MYC、靶基因和 miRNAs 的电路为淋巴瘤发生提供了新的见解，可能有助于新的改善治疗策略。