Molecular Oncology Group, Biodonostia Research Institute, San Sebastián, Gipuzkoa, Spain.
Molecular Oncology Group, Biodonostia Research Institute, San Sebastián, Gipuzkoa, Spain; Radcliffe Department of Medicine, University of Oxford, Oxford, UK; IKERBASQUE, Basque Foundation for Science, Bilbao, Bizkaia, Spain.
Cancer Lett. 2017 Oct 1;405:79-89. doi: 10.1016/j.canlet.2017.07.020. Epub 2017 Jul 27.
MicroRNAs (miRNAs) are small non-coding RNAs that regulate many human genes including those involved in normal B-cell development. When these miRNAs are aberrantly expressed in B-cells they play key pathogenetic roles in the development and maintenance of B-cell lymphomas and by association may serve as useful biomarkers. In this review, we provide an overview of the importance of miRNAs to B-cell lymphomagenesis, as well as considering their use as biomarkers, and their potential usefulness for the clinic.
微小 RNA（miRNAs）是小的非编码 RNA，可以调节许多人类基因，包括参与正常 B 细胞发育的基因。当这些 miRNAs 在 B 细胞中异常表达时，它们在 B 细胞淋巴瘤的发展和维持中发挥关键的致病作用，并可能作为有用的生物标志物。在这篇综述中，我们概述了 miRNAs 对 B 细胞淋巴瘤发生的重要性，以及考虑它们作为生物标志物的用途，以及它们在临床上的潜在用途。
