Todowede Olamide O, Sartorius Benn
Public Health Medicine, University of KwaZulu-Natal College of Health Sciences, Durban, KwaZulu-Natal, South Africa.
School of Nursing and Public Health, UKZN, Durban, KwaZulu-Natal, South Africa.
BMJ Open. 2017 Jul 9;7(7):e016602. doi: 10.1136/bmjopen-2017-016602.
Metabolic disorder and high blood pressure are common complications globally, and specifically among people living with HIV (PLHIV). Diabetes, metabolic syndrome and hypertension are major risk factors for cardiovascular diseases and their related complications. However, the burden of metabolic syndrome, discrete or comorbid diabetes and hypertension in PLHIV compared with HIV-negative population has not been quantified. This review and meta-analysis aims to compare and analyse the prevalence of these trio conditions between HIV-negative and HIV-positive populations in sub-Saharan Africa (SSA).
The Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement guides the methods for this study. Eligibility criteria will be published original articles (English and French language) from SSA that present the prevalence of metabolic syndrome, discrete and/or comorbid diabetes, and hypertension comparisons between PLHIV and HIV-negative populations. The following databases will be searched from January 1990 to February 2017: PubMed/Medline, EBSCOhost, Web of Science, Google Scholar, Scopus, African Index Medicus and Cochrane Database of Systematic Reviews. Eligibility screening and data extraction will be conducted independently by two reviewers, and disagreements resolved by an independent reviewer. Methodological quality and risk of bias will be assessed for individual included studies, while meta-analysis will be used to estimate study outcomes prevalence according to subgroups. Sensitivity analysis will also be performed to further test the robustness of the findings.
This proposed study does not require ethical approval. The results will be published as a scientific article in a peer-reviewed journal, and presented at conferences and to relevant health agencies.
PROSPERO registration number (CRD42016045727).
代谢紊乱和高血压是全球常见的并发症，在艾滋病毒感染者（PLHIV）中尤为常见。糖尿病、代谢综合征和高血压是心血管疾病及其相关并发症的主要危险因素。然而，与未感染艾滋病毒的人群相比，PLHIV中代谢综合征、单纯或合并糖尿病及高血压的负担尚未得到量化。本综述和荟萃分析旨在比较和分析撒哈拉以南非洲（SSA）地区未感染艾滋病毒和感染艾滋病毒人群中这三种疾病的患病率。
系统评价和荟萃分析的首选报告项目声明指导本研究的方法。纳入标准为来自SSA的已发表原创文章（英文和法文），这些文章呈现了PLHIV与未感染艾滋病毒人群之间代谢综合征、单纯和/或合并糖尿病以及高血压的患病率比较。将检索1990年1月至2017年2月的以下数据库：PubMed/Medline、EBSCOhost、科学引文索引、谷歌学术、Scopus、非洲医学索引和Cochrane系统评价数据库。由两名评审员独立进行资格筛选和数据提取，分歧由一名独立评审员解决。对纳入的各个研究进行方法学质量和偏倚风险评估，同时使用荟萃分析根据亚组估计研究结果的患病率。还将进行敏感性分析以进一步检验研究结果的稳健性。
本拟议研究无需伦理批准。研究结果将作为一篇科学文章发表在同行评审期刊上，并在会议上以及向相关卫生机构展示。
PROSPERO注册号（CRD42016045727）。
