子宫内膜异位症女性的心血管代谢风险特征：一项基于人群的研究。

Cardio-Metabolic Risk Profile of Women With Endometriosis: A Population-Based Study.

机构信息

Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

出版信息

Endocrinol Diabetes Metab. 2024 Nov;7(6):e70008. doi: 10.1002/edm2.70008.

DOI:10.1002/edm2.70008

PMID:39400459

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11471882/

Abstract

AIMS

Endometriosis (EM) and metabolic disorders are frequent health problems among reproductive-aged women worldwide. Cardio-metabolic risk profile of women with EM is not well understood. We aimed to investigate the cardio-metabolic risk profile of Iranian reproductive-aged women with EM.

METHODS

This study included 976 female participants aged 20-45 years of Tehran Lipid and Glucose Study. Endometriosis was diagnosed based on the participants' self-reported previous diagnosis of EM, which was confirmed by reviewing the relevant medical documentation. All biochemical measures (low-density lipoprotein cholesterol [LDL], high-density lipoprotein cholesterol [HDL], triglycerides [TG], and fasting blood glucose concentrations [FBG]) and measurement of systolic blood pressure (SBP) and diastolic blood pressure (DBP) and anthropometric parameters were performed according to the standard protocol of TLGS. Logistic regression analysis was performed to estimate the odds ratio of cardio-metabolic disease.

RESULTS

Of the 976 study participants, 161 individuals (16.5%) had a confirmed diagnosis of endometriosis. There were no significant differences in the median of metabolic parameters among women with and without endometriosis (p > 0.05). The prevalence of metabolic syndrome was significantly higher in women with EM group compared to the non-EM group (21.9% vs. 14.9%). The presence of endometriosis was associated with an increased odds of metabolic syndrome (adjusted odds ratio 1.99 [95% CI 1.20-3.30]; p = 0.007). And endometriosis significantly increased odds of low HDL by 2.07 (1.02-4.20); after adjustment, it still remained significant (p = 0.03). Endometriosis also increased odds of high waist circumstance significantly (1.58 [1.06-2.37]; p = 0.02).

CONCLUSIONS

Women with endometriosis may be at an increased risk of developing metabolic syndrome, high waist circumstance and low HDL compared to their counterparts without the condition. Given the potential cardio-metabolic implications, healthcare providers should consider assessing the metabolic profile of women diagnosed with endometriosis.

摘要

目的

子宫内膜异位症（EM）和代谢紊乱是全球育龄妇女常见的健康问题。患有 EM 的女性的心血管代谢风险状况尚不清楚。我们旨在研究伊朗育龄期患有 EM 的女性的心血管代谢风险状况。

方法

本研究纳入了 976 名年龄在 20-45 岁的德黑兰血脂和血糖研究参与者。根据参与者自述的先前 EM 诊断，诊断子宫内膜异位症，通过查阅相关医疗记录进行确认。根据 TLGS 的标准方案，进行所有生化指标（低密度脂蛋白胆固醇 [LDL]、高密度脂蛋白胆固醇 [HDL]、甘油三酯 [TG]和空腹血糖浓度 [FBG]）和收缩压（SBP）和舒张压（DBP）以及人体测量参数的测量。使用逻辑回归分析估计心血管代谢疾病的比值比。

结果

在 976 名研究参与者中，有 161 人（16.5%）被确诊患有子宫内膜异位症。患有和不患有子宫内膜异位症的女性之间，代谢参数的中位数没有显著差异（p > 0.05）。患有子宫内膜异位症的女性中代谢综合征的患病率明显高于非子宫内膜异位症组（21.9%比 14.9%）。子宫内膜异位症与代谢综合征的患病风险增加相关（调整后的比值比 1.99 [95%CI 1.20-3.30]；p = 0.007）。子宫内膜异位症还使 HDL 降低的风险增加 2.07 倍（1.02-4.20）；调整后仍然显著（p = 0.03）。子宫内膜异位症还使高腰围的风险显著增加（1.58 [1.06-2.37]；p = 0.02）。