Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Sci Rep. 2017 Jul 10;7(1):5019. doi: 10.1038/s41598-017-05258-4.
Although ocular circulation at the retina and optic disc is known to be associated with the pathology of glaucoma, direct measurement of blood flow velocity has been difficult to obtain. This prospective observational study enrolled 11 consecutive patients with treatment-naïve primary open-angle glaucoma (POAG) and 11 healthy subjects, and the effects of topical tafluprost treatment on ocular circulation were examined at baseline and at 1, 4, and 12 weeks after initiating treatment with topical tafluprost on POAG patients using multiple modalities, which include adaptive optics scanning laser ophthalmoscopy (AOSLO). Baseline mean intraocular pressure (IOP) was significantly higher and mean parafoveal blood flow velocity (pBFV) was significantly lower in POAG eyes than in healthy eyes. Mean IOP was significantly decreased (1 week, -19.1%; 4 weeks, -17.7%; and 12 weeks, -23.5%; all P < 0.001) and mean pBFV was significantly increased from the baseline at all follow-up periods after initiating treatment (1 week, 14.9%, P = 0.007; 4 weeks, 21.3%, P < 0.001; and 12 weeks, 14.3%, P = 0.002). These results reveal that tafluprost may not only lower IOP but may also improve retinal circulation in POAG eyes and AOSLO may be useful to evaluate retinal circulatory change after treatment.
虽然已知视网膜和视盘的眼循环与青光眼的病理学有关，但直接测量血流速度一直很困难。这项前瞻性观察研究纳入了 11 名未经治疗的原发性开角型青光眼（POAG）患者和 11 名健康受试者，使用包括自适应光学扫描激光检眼镜（AOSLO）在内的多种方式，在 POAG 患者开始使用他氟前列素滴眼剂治疗的基线以及治疗后 1、4 和 12 周，检查眼循环的变化。POAG 眼的基线平均眼内压（IOP）显著升高，平均旁中心血流速度（pBFV）显著降低。IOP 平均下降（1 周，-19.1%；4 周，-17.7%；12 周，-23.5%；均 P<0.001），治疗开始后所有随访期间的平均 pBFV 均从基线显著增加（1 周，14.9%，P=0.007；4 周，21.3%，P<0.001；12 周，14.3%，P=0.002）。这些结果表明，他氟前列素不仅可能降低 IOP，还可能改善 POAG 眼的视网膜循环，AOSLO 可能有助于评估治疗后视网膜循环的变化。
