Weindler Hannah, Spitzer Martin S, Schultheiß Maximilian, Kromer Robert
Department of Ophthalmology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
BMC Ophthalmol. 2020 Nov 12;20(1):444. doi: 10.1186/s12886-020-01707-3.
Primary open-angle glaucoma (POAG) is a progressive neurodegenerative disease which leads to irreversible blindness. An elevated intraocular pressure (IOP) is considered to be the main risk factor for the disease progression. It is known that retinal blood flow is altered in POAG eyes. Tafluprost, a prostaglandin analogue which lowers the IOP, has shown to also improve the retinal blood flow in animals.
The current study therefore evaluated the retinal vessel density in the peripapillary and macular region of POAG patients with normal IOP treated with topical Tafluprost (n = 20) compared to surgically treated patients with normal IOP (n = 22) using optical coherence tomography angiography (OCT-A). The retinal flow density was obtained after binarisation and evaluated in five sectors.
There was a significantly higher peripapillary flow density in all sectors in Tafluprost treated eyes when compared to post-surgery eyes. The flow density in the inferior sector of the superficial plexus in the macular region was also significantly higher in the Tafluprost group.
These results indicate that Tafluprost not only lowers IOP, but may also enhance retinal blood flow in POAG patients with a normal IOP.
原发性开角型青光眼（POAG）是一种进行性神经退行性疾病，可导致不可逆的失明。眼压升高被认为是疾病进展的主要危险因素。已知POAG患者的视网膜血流会发生改变。他氟前列素是一种降低眼压的前列腺素类似物，已显示在动物中也能改善视网膜血流。
因此，本研究使用光学相干断层扫描血管造影（OCT-A）评估了局部使用他氟前列素治疗的眼压正常的POAG患者（n = 20）与手术治疗的眼压正常的患者（n = 22）在视乳头周围和黄斑区域的视网膜血管密度。在二值化后获得视网膜血流密度，并在五个扇区进行评估。
与术后眼睛相比，他氟前列素治疗的眼睛在所有扇区的视乳头周围血流密度均显著更高。他氟前列素组黄斑区浅表丛下部扇区的血流密度也显著更高。
这些结果表明，他氟前列素不仅能降低眼压，还可能增强眼压正常的POAG患者的视网膜血流。
