Duim Herman, Otto Sijbren
Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Beilstein J Org Chem. 2017 Jun 21;13:1189-1203. doi: 10.3762/bjoc.13.118. eCollection 2017.
In this review we discuss systems of self-replicating molecules in the context of the origin of life and the synthesis of de novo life. One of the important aspects of life is the ability to reproduce and evolve continuously. In this review we consider some of the prerequisites for obtaining unbounded evolution of self-replicating molecules and describe some recent advances in this field. While evolution experiments involving self-replicating molecules have shown promising results, true open-ended evolution has not been realized so far. A full understanding of the requirements for open-ended evolution would provide a better understanding of how life could have emerged from molecular building blocks and what is needed to create a minimal form of life in the laboratory.
在本综述中，我们在生命起源和从头合成生命的背景下讨论了自我复制分子系统。生命的一个重要方面是能够持续繁殖和进化。在本综述中，我们考虑了实现自我复制分子无界进化的一些先决条件，并描述了该领域的一些最新进展。虽然涉及自我复制分子的进化实验已显示出有希望的结果，但到目前为止尚未实现真正的开放式进化。全面了解开放式进化的要求将有助于更好地理解生命如何从分子构建块中出现，以及在实验室中创造最小形式的生命需要什么。
