Immunomodulating and Revascularizing Activity of Synergize with Fungicide Activity of Biogenic Peptide Cecropin P1.

Previously transgenic plants producing an antimicrobial peptide cecropin P1 (CecP1) have been reported. Now we report biological testing extracts containing CecP1 as a candidate drug for treatment of wounds infected with The drug constitutes the whole juice from leaves (not ethanol extract) sterilized with nanofiltration. A microbicide activity of CecP1 against an animal fungal pathogen in vivo was demonstrated for the first time. However, a favorable therapeutic effect of the transgenic extract was attributed to a synergism between the fungicide activity of CecP1 and wound healing (antiscar), revascularizing, and immunomodulating effect of natural biologically active components of . A commercial fungicide preparation clotrimazole eliminated cells within infected wounds in rats with efficiency comparable to CecP1-enriched extract. But in contrast to extract, clotrimazole did not exhibit neither wound healing activity nor remodeling of the scar matrix. Taken together, our results allow assumption that CecP1-enriched extracts should be considered as a candidate drug for treatment of dermatomycoses, wounds infected with fungi, and bedsores.